Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism
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DOI: 10.1007/s00204-020-02916-x
Abstract: The pregnane X receptor (PXR, encoded by the NR1I2 gene) is a ligand-regulated transcription factor originally described as a master regulator of xenobiotic detoxification. Later, however, PXR was also shown to interact with endogenous metabolism… read more here.
Keywords: pxr expression; expression; drug metabolism; regulation ... See more keywords