Screening a knowledge‐based library of low molecular weight compounds against the proline biosynthetic enzyme 1‐pyrroline‐5‐carboxylate 1 (PYCR1)
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DOI: 10.1002/pro.5072
Abstract: Δ1‐pyrroline‐5‐carboxylate reductase isoform 1 (PYCR1) is the last enzyme of proline biosynthesis and catalyzes the NAD(P)H‐dependent reduction of Δ1‐pyrroline‐5‐carboxylate to L‐proline. High PYCR1 gene expression is observed in many cancers and linked to poor patient… read more here.
Keywords: pyrroline carboxylate; carboxylate; pycr1; low molecular ... See more keywords
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells
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DOI: 10.1080/21655979.2022.2052673
Abstract: ABSTRACT Shikonin(SK) is a natural small molecule naphthoquinone compound, which has anti-cancer activity in various human malignant tumors. Pyrroline-5-carboxylate reductase 1(PYCR1) is involved in tumorigenesis and regulates various cellular processes, including growth, invasion, migration, and… read more here.
Keywords: hepatocellular carcinoma; pycr1; pyrroline carboxylate; apoptosis autophagy ... See more keywords
Abstract 2505: PYCR1 inhibition in multiple myeloma-associated stroma limits tumor growth
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2505
Abstract: Introduction Multiple myeloma (MM) is a hematological cancer, characterized by the accumulation of monoclonal plasma cells in the bone marrow. It remains an incurable cancer due to drug resistance, wherein the bone marrow microenvironment plays… read more here.
Keywords: pycr1 inhibition; myeloma; expression; pycr1 ... See more keywords
BHLHE41 inhibits bladder cancer progression via regulation of PYCR1 stability and thus inactivating PI3K/AKT signaling pathway
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DOI: 10.1186/s40001-024-01889-2
Abstract: The basic helix-loop-helix family member e41 (BHLHE41) is frequently dysregulated in tumors and plays a crucial role in malignant progression of various cancers. Nevertheless, its specific function and underlying mechanism in bladder cancer (BCa) remain… read more here.
Keywords: bhlhe41; pi3k akt; bladder cancer; pycr1 ... See more keywords
Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells
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DOI: 10.3389/fcell.2021.604756
Abstract: Murphy Roths Large (MRL) mice possess outstanding capacity to regenerate several tissues. In the present study, we investigated whether this regenerative potential could be associated with the intrinsic particularities possessed by their mesenchymal stem cells… read more here.
Keywords: pycr1; regenerative potential; mscs; mrl mscs ... See more keywords