Activation of Pyk2 by CaM kinase II in cultured hypothalamic neurons and gonadotroph cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27443
Abstract: Gonadotropin‐releasing hormone (GnRH) is secreted from hypothalamic GnRH neurons and stimulates a GnRH receptor in gonadotroph cells and GnRH neurons. The GnRH receptor belongs to the G‐protein‐coupled receptors, and stimulation of the GnRH receptor activates… read more here.
Keywords: kinase; pyk2; cam kinase; activation ... See more keywords
The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63426-5
Abstract: The striatum is critical for cocaine-induced locomotor responses. Although the role of D1 receptor-expressing neurons is established, underlying molecular pathways are not fully understood. We studied the role of Pyk2, a non-receptor, calcium-dependent protein-tyrosine kinase.… read more here.
Keywords: locomotor; pyk2; tyrosine; expressing neurons ... See more keywords
PYK2 is overexpressed in chronic lymphocytic leukaemia: A potential new therapeutic target
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17688
Abstract: Chronic Lymphocytic Leukaemia (CLL) is the most common adult B‐cell leukaemia and despite improvement in patients' outcome, following the use of targeted therapies, it remains incurable. CLL supportive microenvironment plays a key role in both… read more here.
Keywords: pyk2; cll; lymphocytic leukaemia; fak pyk2 ... See more keywords
The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.1a0217-063r
Abstract: Monocytes are short‐lived myeloid cells that perform functions essential for tissue homeostasis and disease resolution. However, the cellular mechanisms controlling the maintenance and turnover of monocyte populations are largely undefined. Proline‐rich tyrosine kinase 2 (Pyk2)… read more here.
Keywords: kinase pyk2; pyk2; monocyte populations; steady state ... See more keywords
Proline-rich tyrosine kinase Pyk2 regulates deep vein thrombosis.
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.279703
Abstract: Deep vein thrombosis results from the cooperative action of leukocytes, platelets, and endothelial cells. The proline-rich tyrosine kinase Pyk2 regulates platelet activation and supports arterial thrombosis. In this study, we combined pharmacological and genetic approaches… read more here.
Keywords: deep vein; thrombosis; pyk2; vein thrombosis ... See more keywords
Tyrosine kinase Pyk2 is involved in colonic smooth muscle contraction via the RhoA/ROCK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological research"
DOI: 10.33549/physiolres.933857
Abstract: The contraction of gastrointestinal (GI) smooth muscles is regulated by both Ca(2+)-dependent and Ca(2+) sensitization mechanisms. Proline-rich tyrosine kinase 2 (Pyk2) is involved in the depolarization-induced contraction of vascular smooth muscle via a Ca(2+) sensitization… read more here.
Keywords: kinase; pyk2 involved; smooth muscle; contraction ... See more keywords
Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415475
Abstract: PyK2 is a member of the proline-rich tyrosine kinase and focal adhesion kinase families and is ubiquitously expressed. PyK2 is mainly activated by stimuli, such as activated Src kinases and intracellular acidic pH. The mechanism… read more here.
Keywords: pyk2; associated molecules; cancer metastasis; milieu ... See more keywords
Pyk2 promotes tumor progression in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.9412
Abstract: Proline-rich tyrosine kinase 2 (Pyk2), a member of the focal adhesion kinase family, has recently been associated with tumor development. However, the role of Pyk2 in renal cell carcinoma (RCC) remains unexplored. The present study… read more here.
Keywords: renal cell; cell carcinoma; rcc; pyk2 ... See more keywords