A cheap, simple high throughput method for screening native Helicobacter pylori urease inhibitors using a recombinant Escherichia coli, its validation and demonstration of Pistacia atlantica methanolic extract effectivity and specificity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of microbiological methods"
DOI: 10.1016/j.mimet.2016.11.022
Abstract: Helicobacter pylori is the most frequent and persistent bacterial infection worldwide, and a risk factor for active gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Although combined antibiotics treatment is effective cases of… read more here.
Keywords: methanolic extract; recombinant escherichia; urease inhibitors; escherichia coli ... See more keywords
Neutralizing antibodies for Helicobacter pylori urease inhibit bacterial colonization in the murine stomach in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical research"
DOI: 10.2220/biomedres.40.87
Abstract: Helicobacter pylori (H. pylori) urease is a key protein for persistent infection of the bacteria in the stomach. Although H. pylori generally induce anti-H. pylori-specific antibodies (Abs), these Abs do not usually work for eradication… read more here.
Keywords: infection; colonization; stomach; mice ... See more keywords
Helicobacter pylori Urease: Potential Contributions to Alzheimer’s Disease
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DOI: 10.3390/ijms23063091
Abstract: Alzheimer’s disease (AD) causes dementia and memory loss in the elderly. Deposits of beta-amyloid peptide and hyperphosphorylated tau protein are present in a brain with AD. A filtrate of Helicobacter pylori’s culture was previously found… read more here.
Keywords: pylori urease; alzheimer disease; hpu; helicobacter pylori ... See more keywords
Zerumbone Inhibits Helicobacter pylori Urease Activity
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26092663
Abstract: Helicobacter pylori (H. pylori) produces urease in order to improve its settlement and growth in the human gastric epithelium. Urease inhibitors likely represent potentially powerful therapeutics for treating H. pylori; however, their instability and toxicity… read more here.
Keywords: zerumbone; urease activity; urease; pylori urease ... See more keywords