Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56157-9
Abstract: [Pyr1]apelin-13 is the predominant apelin peptide isoform in the human cardiovascular system and plasma. To date, few studies have investigated [Pyr1]apelin-13 metabolism in vivo in rats with no studies examining its stability in humans. We… read more here.
Keywords: detection quantification; apelin; pyr1 apelin; method detection ... See more keywords
Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta.
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DOI: 10.2174/0929866529666220516141317
Abstract: BACKGROUND Apelin is a newly discovered peptide hormone and originally discovered endogenous apelin receptor ligand. OBJECTIVE In this study, we aimed to investigate the possible roles of potassium channel subtypes in the vasorelaxant effect mechanisms… read more here.
Keywords: vasorelaxant effect; pyr1 apelin; effect; rat thoracic ... See more keywords