Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex
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DOI: 10.1016/j.neuroscience.2020.10.022
Abstract: Activation of specific neural circuits in different layers of the primate dorsolateral prefrontal cortex (DLPFC) is essential for working memory, a core cognitive function. Recurrent excitation between pyramidal neurons in middle and deep layers of… read more here.
Keywords: pyramidal; pyramidal neurons; cortical pyramidal; pyramidal neuron ... See more keywords
Activation of cortical somatostatin interneurons prevents the development of neuropathic pain
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DOI: 10.1038/nn.4595
Abstract: Neuropathic pain involves long-lasting modifications of pain pathways that result in abnormal cortical activity. How cortical circuits are altered and contribute to the intense sensation associated with allodynia is unclear. Here we report a persistent… read more here.
Keywords: neuropathic pain; activation; somatostatin; pyramidal neuron ... See more keywords
Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells
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DOI: 10.1038/nn.4624
Abstract: The neocortex comprises multiple information processing streams mediated by subsets of glutamatergic pyramidal cells (PCs) that receive diverse inputs and project to distinct targets. How GABAergic interneurons regulate the segregation and communication among intermingled PC… read more here.
Keywords: neuron ensembles; chandelier cells; inhibitory control; selective inhibitory ... See more keywords
Spared CA1 pyramidal neuron function and hippocampal performance following antisense knockdown of microRNA‐134
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DOI: 10.1111/epi.14475
Abstract: Inhibition of microRNA‐134 by an oligonucleotide antagomir (ant‐134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess… read more here.
Keywords: microrna 134; spared ca1; ca1 pyramidal; function hippocampal ... See more keywords
Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex
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DOI: 10.3389/fphar.2017.00899
Abstract: Caffeine is the most widely used psychoactive drug, bolstering attention and normalizing mood and cognition, all functions involving cerebral cortical circuits. Whereas studies in rodents showed that caffeine acts through the antagonism of inhibitory A1… read more here.
Keywords: neuron excitability; caffeine; pyramidal neuron; synaptic transmission ... See more keywords