Synthesis, experimental and theoretical studies on highly functionalized novel 4H-pyran-3-carboxylate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.08.037
Abstract: Abstract A facile methodology for the synthesis of a multifunctional 4H-pyran -3-carboxylate, 2-(methacryloyloxy)ethyl 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate (1) via a single-step multicomponent reaction of 2-(methacryloyloxy)ethyl 3-oxobutanoate with an aldehyde and malononitrile utilizing K2CO3 as a catalyst in aqueous… read more here.
Keywords: pyran; experimental theoretical; synthesis experimental; pyran carboxylate ... See more keywords
Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles
Sign Up to like & getrecommendations! Published in 2019 at "Communications Chemistry"
DOI: 10.1038/s42004-019-0177-5
Abstract: Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles. Here we show the development of catalytic stereoselective annulation reactions that afford spirooxindole… read more here.
Keywords: spirooxindole pyran; carbon; aldol oxa; pyran ... See more keywords
Synthesis and in vitro evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00366h
Abstract: Tuberculosis is an ever-evolving infectious disease that urgently needs new drugs. In the search for new antituberculosis agents, a library of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) (2a-2y) was synthesized and evaluated against a standard virulent laboratory strain of… read more here.
Keywords: antituberculosis agents; evaluation; antituberculosis; pyran ... See more keywords
Thieno[3,2-c]pyran: an ESIPT based fluorescence “turn-on” molecular chemosensor with AIE properties for the selective recognition of Zn2+ ion
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj02236e
Abstract: Excited state intramolecular proton transfer (ESIPT) based functionalized thieno[3,2-c]pyran P was designed and synthesized as a fluorescent turn-on chemosensor for the selective recognition of Zn2+ ion with a low detection limit (0.67 μM). Fourier transform… read more here.
Keywords: esipt based; thieno pyran; zn2; selective recognition ... See more keywords
Crystal structure and Hirshfeld surface analysis of ethyl 2′-amino-5-bromo-3′-cyano-6′-methyl-2-oxospiro[indoline-3,4′-pyran]-5′-carboxylate
Sign Up to like & getrecommendations! Published in 2022 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989022008271
Abstract: In the title structure, the 2,3-dihydro-1H-indole ring system is nearly planar, while the conformation of the 4H-pyran ring is close to a flattened boat. The mean planes of these fragments are approximately perpendicular to each… read more here.
Keywords: structure; surface analysis; structure hirshfeld; pyran ... See more keywords
Crystal Structure and Molecular Conformational Studies of Allyl 6-Amino-5-cyano-4-(4-fluorophenyl)-2-methyl-4H-pyran-3-carboxylate
Sign Up to like & getrecommendations! Published in 2019 at "Crystallography Reports"
DOI: 10.1134/s1063774519070101
Abstract: The allyl 6-amino-5-cyano-4-(4-fluorophenyl)-2-methyl-4H-pyran-3-carboxylate, C17H15FN2O3, compound adopts a triclinic crystal system with the sp. gr. $$P\bar {1}$$, Z = 2. The 4H-pyran ring adopts a boat conformation with their respective parameters (Q = 0.2384(26) A, θ… read more here.
Keywords: fluorophenyl methyl; cyano fluorophenyl; allyl amino; amino cyano ... See more keywords
tert-Butyl(2-oxo-2H-pyran-5-yl)carbamate as the First Chameleon Diene Bearing an Electron-Donating Substituent
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175666
Abstract: The 2(H)-pyran-2-one bearing electron-donating tert-butylcarbamate (BocNH-) group at the 5- position is a “chameleon” diene and undergoes efficient Diels–Alder cycloadditions with alkene dienophiles with both electron-rich and electron-deficient substituents. Cycloadditions afford the 5-substituted bicyclic lactone… read more here.
Keywords: bearing electron; electron; electron donating; pyran ... See more keywords
Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0279
Abstract: Aim: Synthesis of novel pyran-based uracils that may have potent antitumor activity against hepatocellular carcinoma HepG2 and ovarian cancer SKOV3 cell lines. Materials & methods: Novel pyran-based uracils were synthesized and their anticancer activity was… read more here.
Keywords: antitumor activity; novel pyran; pyran; docking studies ... See more keywords