Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase
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DOI: 10.1002/cmdc.202200411
Abstract: A series of 22 different 3,5‐diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones (DATPs) were synthesized, characterized, and screened for their in vitro antiplasmodial activities against chloroquine (CQ)‐sensitive Pf3D7, CQ‐resistant PfINDO, and artemisinin‐resistant PfMRA‐1240 strains of Plasmodium falciparum. DATP 19 (3,5‐bis(4‐hydroxy‐3,5‐dimethoxybenzylidene)tetrahydro‐2H‐pyran‐4(3H)‐one) was found… read more here.
Keywords: plasmodium falciparum; pyran ones; tetrahydro pyran; diarylidenetetrahydro pyran ... See more keywords
Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid
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DOI: 10.1007/s10593-019-02542-1
Abstract: Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were… read more here.
Keywords: methyl; multicomponent reaction; hydroxy methyl; reaction hydroxy ... See more keywords
A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet
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DOI: 10.1007/s10600-017-1906-6
Abstract: A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent… read more here.
Keywords: derivative anti; new pyran; one derivative; alpinia zerumbet ... See more keywords
Condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. Synthesis and properties of 2-aryl-1-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)ethane-1,2-diones
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2301-6
Abstract: A convenient method was developed for the synthesis of previously unknown 1,2-diketones, based on the condensation of 5-hydroxy-2-methyl-4H-pyran-4-one with arylglyoxals. The study demonstrated the possibility of using these compounds to synthesize nitrogen-containing hetero cyclic systems… read more here.
Keywords: methyl; hydroxy methyl; condensation hydroxy; methyl pyran ... See more keywords
Caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one isolated from the leaves of Olinia usambarensis attenuates LPS-induced inflammatory mediators by inactivating AP-1 and NF-κB.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.06.031
Abstract: We have previously reported the isolation of four compounds, caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one (CDMP), olinioside, caffeic acid and 3-hydroxylup-12-en-28-oic acid, from the leaves of Olinia usambarensis. Here, we evaluated the inhibitory effects of these compounds on lipopolysaccharide (LPS)-induced… read more here.
Keywords: caffeoyloxy dihydro; lps induced; dihydro methyl; inflammatory mediators ... See more keywords
Design, synthesis and biological evaluation of 2-substituted 3-hydroxy-6-methyl-4H-pyran-4-one derivatives as Pseudomonas aeruginosa biofilm inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.041
Abstract: Drug-resistant bacteria associated with biofilm formation are rapidly on the rise, requiring novel therapeutic options to combat biofilm induced drug-resistance. In this study, a class of 3-hydroxy-2-(phenylhydroxy-methyl)-6-methyl-4H-pyran-4-one derivatives (1a-1e) were found by screening of an… read more here.
Keywords: methyl; pseudomonas aeruginosa; one derivatives; methyl pyran ... See more keywords
Catalytic asymmetric borylative aldol reaction of 5,6-dihydro-2H-pyran-2-one and ketones
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DOI: 10.1016/j.tet.2018.11.041
Abstract: Abstract A copper(I)-catalyzed asymmetric borylative aldol reaction of 5,6-dihydro-2H-pyran-2-one and simple ketones (including aromatic ketones and an aliphatic ketone) was disclosed, which afforded a series of chiral diols after an oxidative work-up in moderate yields… read more here.
Keywords: aldol reaction; dihydro pyran; asymmetric borylative; borylative aldol ... See more keywords
Synthesis and solid-state luminescence of highly-substituted 6-amino-2H-pyran-2-one derivatives
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DOI: 10.1016/j.tetlet.2020.152084
Abstract: Abstract A fast and convenient synthesis and solid-state luminescence properties of new highly-substituted 6-amino-2H-pyran-2-one derivatives is described. These compounds were obtained from inexpensive and available 2-acyl(aroyl)-1,3-dicyano-1,3-bis-methoxycarbonylpropenides via regioselective heterocyclization under the action of sulfuric and… read more here.
Keywords: solid state; state luminescence; amino pyran; synthesis solid ... See more keywords
Colletochlorins E and F, New Phytotoxic Tetrasubstituted Pyran-2-one and Dihydrobenzofuran, Isolated from Colletotrichum higginsianum with Potential Herbicidal Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.6b05193
Abstract: A new tetrasubstituted pyran-2-one and a new dihydrobenzofuran, named colletochlorins E and F (1 and 2, respectively), were isolated from the culture filtrates of the fungus Colletotrichum higginsianum together with the already known colletochlorin A,… read more here.
Keywords: tetrasubstituted pyran; dihydrobenzofuran; colletotrichum higginsianum; pyran one ... See more keywords
Syntheses and Phytotoxicity of All Stereoisomers of 6-(2-Hydroxy-6-phenylhex-1-yl)-5,6-dihydro-2H-pyran-2-one and Determination of Effect of α,β-Unsaturated Carbonyl Structure and Hydroxy Group Bonding to Chiral Carbon.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b05507
Abstract: All four stereoisomers of naturally occurring 6-(2-hydroxy-6-phenylhex-1-yl)-5,6-dihydro-2H-pyran-2-one (1) were synthesized by employing yeast-reduction products with high optical purity (95%ee-more than 99% ee), and then their phytotoxicities against lettuce and Italian ryegrass were evaluated. In the… read more here.
Keywords: seed; phenylhex dihydro; hydroxy group; pyran one ... See more keywords
3-Ethyl-6-vinyltetrahydro-2H-pyran-2-one (EVP): a versatile CO2-derived lactone platform for polymer synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03516b
Abstract: 3-Ethyl-6-vinyltetrahydro-2H-pyran-2-one (EVP) is a CO2-derived lactone synthesized via Pd-catalyzed telomerization of butadiene. As EVP is 28.9% by weight CO2, it has received significant recent attention as an intermediary for the synthesis of high CO2-content polymers.… read more here.
Keywords: vinyltetrahydro pyran; ethyl vinyltetrahydro; evp; one evp ... See more keywords