Synthesis of Pyranones: Ru-Catalyzed Cascade Reaction via Vinylic C-H Addition to Glyoxylate.
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DOI: 10.1021/acs.orglett.2c01614
Abstract: The efficient synthesis of pyranones is presented by a three-component cascade reaction from readily available acrylic acids, ethyl glyoxylate, and p-toluenesulfonamide under ruthenium catalysis. For the first time, the nucleophilic addition of the vinylic C-H… read more here.
Keywords: addition; catalyzed cascade; synthesis pyranones; pyranones catalyzed ... See more keywords