Discovery of Novel Benzo[4,5]imidazo[1,2-a]pyrazin-1-amine-3-amide-one Derivatives as Anticancer Human A2A Adenosine Receptor Antagonists.
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DOI: 10.1021/acs.jmedchem.2c00101
Abstract: The blockade of A2A adenosine receptor (A2AAR) activates immunostimulatory response through regulating signaling in tumor microenvironment. Thus, A2AAR has been proposed as a promising target for cancer immunotherapy. In this work, we designed a new… read more here.
Keywords: a2a adenosine; adenosine; benzo imidazo; pyrazin amine ... See more keywords