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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.06.064
Abstract: A series of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides was designed and synthesized as new tropomyosin receptor kinases (Trks) inhibitors by utilizing a structure-guided optimization strategy. One of the most potent compounds 9o suppressed TrkA/B/C with IC50 values of 2.65,…
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Keywords:
pyrazin ylethynyl;
imidazo pyrazin;
tropomyosin receptor;
ylethynyl methylbenzamides ... See more keywords