An EDTA-resistant pyrazinamidase from non-pathogen Pseudonocardia carboxydivorans
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DOI: 10.1007/s10529-020-02890-5
Abstract: To characterize a pyrazinamidase from non-pathogen Pseudonocardia carboxydivorans. A pyrazinamidase gene pncA encoding a 23-kDa protein PncA-Pse from P. carboxydivorans was over-expressed in Escherichia coli and characterized. This PncA-Pse can convert both pyrazinamide and nicotinamide… read more here.
Keywords: non pathogen; pyrazinamidase; pathogen pseudonocardia; pyrazinamidase non ... See more keywords
Structural insights of catalytic mechanism in mutant pyrazinamidase of Mycobacterium tuberculosis
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DOI: 10.1080/07391102.2020.1761879
Abstract: Abstract Pyrazinamidase (PZase) is a member of Fe-dependent amidohydrolases that activates pyrazinamide (PZA) into active pyrazinoic acid (POA). PZA, a nicotinamide analogue, is an essential first-line drug used in Mycobacterium tuberculosis (Mtb) treatment. The active… read more here.
Keywords: mechanism; tuberculosis; pza; pyrazinamidase ... See more keywords