The thermal behavior of pyrazinamide in 12 solvents from 288.15 to 328.15 k
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115572
Abstract: Abstract The solubility of pyrazinamide in twelve pure solvents was measured from 288.15k to 328.15k.The experimental data were correlated by the modified Apelblat model, λh equation, Wilson model and NRTL model, and the modified Apelblat… read more here.
Keywords: pyrazinamide; thermal behavior; pyrazinamide solvents; solvents 288 ... See more keywords
Intermediate Susceptibility Dose-Dependent Breakpoints For High-Dose Rifampin, Isoniazid, and Pyrazinamide Treatment in Multidrug-Resistant Tuberculosis Programs
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DOI: 10.1093/cid/ciy346
Abstract: Background Bacterial susceptibility is categorized as susceptible, intermediate-susceptible dose-dependent (ISDD), and resistant. The strategy is to use higher doses of first-line agents in the ISDD category, thereby preserving the use of these drugs. This system… read more here.
Keywords: rifampin isoniazid; susceptibility; treatment; dose dependent ... See more keywords
Population Pharmacokinetic Modelling and Limited Sampling Strategies for Therapeutic Drug Monitoring of Pyrazinamide in Patients with Tuberculosis
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DOI: 10.1128/aac.00003-22
Abstract: Pyrazinamide is one of the first-line antituberculosis drugs. The efficacy of pyrazinamide is associated with the ratio of 24-h area under the concentration–time curve (AUC24) to MIC. ABSTRACT Pyrazinamide is one of the first-line antituberculosis… read more here.
Keywords: poppk model; therapeutic drug; limited sampling; population pharmacokinetic ... See more keywords
Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis
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DOI: 10.1128/mbio.00439-21
Abstract: For decades, pyrazinamide has served as a cornerstone of tuberculosis therapy. Unlike any other antitubercular drug, pyrazinamide requires an acidic environment to exert its action. ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis… read more here.
Keywords: tuberculosis; stress response; susceptibility; pyrazinamide ... See more keywords
Evaluating the Frequency of Resistance to Pyrazinamide Among Drug-resistant Strains of Mycobacterium tuberculosis in Isfahan, Iran
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Clinical Infectious Diseases"
DOI: 10.5812/archcid.101092
Abstract: Background: Pyrazinamide is one of the most important first-line medications for the treatment of tuberculosis and an alternative intake for MDR-TB and XDR-TB patients. Objectives: The purpose of this study was to evaluate resistance to… read more here.
Keywords: pyrazinamide; mycobacterium tuberculosis; drug; resistance pyrazinamide ... See more keywords