Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing
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DOI: 10.1128/aac.00046-21
Abstract: Pyrazinamide is a first-line drug used in the treatment of tuberculosis. High exposure to pyrazinamide and its metabolites may result in hepatotoxicity, whereas low exposure to pyrazinamide has been correlated with treatment failure of first-line… read more here.
Keywords: patients coinfected; individualized dosing; treatment; exposure ... See more keywords