Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses.
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DOI: 10.1016/j.molcel.2021.10.003
Abstract: Viral RNA-dependent RNA polymerases (RdRps) are a target for broad-spectrum antiviral therapeutic agents. Recently, we demonstrated that incorporation of the T-1106 triphosphate, a pyrazine-carboxamide ribonucleotide, into nascent RNA increases pausing and backtracking by the poliovirus… read more here.
Keywords: intra intermolecular; template switching; pyrazine carboxamide; intermolecular template ... See more keywords