Physicochemical profile of Os (III) complexes with pyrazine derivatives: From solution behavior to DNA binding studies and biological assay
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113804
Abstract: Abstract New series of osmium(III) complexes with pyrazinamide (PZA) and its analogues (PTCA, PAOX) were synthesized. The physicochemical features in the solid phase have been identified and confirmed using elemental analysis, mass spectrometry, spectroscopic techniques… read more here.
Keywords: iii; physicochemical profile; pyrazine derivatives; dna ... See more keywords
In search of HIV entry inhibitors using molecular docking, ADME and toxicity studies of some Thiazolidinone-Pyrazine derivatives against CXCR4 co-receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Current HIV research"
DOI: 10.2174/1570162x20666220214123331
Abstract: BACKGROUND Entry inhibitors prevent binding of human immunodeficiency virus protein to the chemokine receptor CXCR4 and are used along with conventional anti-HIV therapy. They aid in restoring immunity and can prevent the development of HIV-TB… read more here.
Keywords: hiv; entry; entry inhibitors; toxicity ... See more keywords
Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.815534
Abstract: In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines in vitro. Most… read more here.
Keywords: compound 17l; triazolo pyrazine; vegfr; pyrazine derivatives ... See more keywords