Design, synthesis, and biological evaluation of new pyrazino[1,2‐a]benzimidazole derivatives as selective cyclooxygenase (COX‐2) inhibitors
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DOI: 10.1002/ardp.201800265
Abstract: A new class of pyrazino[1,2‐a]benzimidazole derivatives possessing the SO2Me pharmacophore at the para position of the C‐3 phenyl ring was designed, synthesized, and tested for their cyclooxygenase‐2 (COX‐2) inhibitory, anti‐cancer and anti‐platelet aggregation activities. In… read more here.
Keywords: pyrazino benzimidazole; cox; cyclooxygenase cox; benzimidazole derivatives ... See more keywords