Zinc‐Catalysed [3+2] Cycloaddition of Enaminone with Tosylhydrazide to Synthesise 1H‐pyrazole via C–N and S–N Bond Cleavage
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400549
Abstract: A novel and practical zinc‐catalysed synthesis of 1H‐pyrazole has been developed. The one‐pot protocol enables the cycloaddition of enaminone and tosylhydrazide via C–N and S–N bond breaking process, leading to diverse mono‐substituted pyrazole derivatives in… read more here.
Keywords: enaminone tosylhydrazide; via bond; cycloaddition enaminone; zinc catalysed ... See more keywords
An Efficient and Facile Synthesis of Functionalized Indole-3-yl Pyrazole Derivatives Starting from 3-Cyanoacetylindole
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2654
Abstract: The versatile hitherto reported 3-(1H-indol-3-yl)-1H-pyrazol-5-amine () was synthesized by the reaction of 3-cyanoacetylindole () with hydrazine hydrate in refluxing ethanol and used as a key intermediate for the synthesis of novel pyrazolo[1,5-a]pyrimidines via its reactions… read more here.
Keywords: pyrazole; synthesis functionalized; facile synthesis; functionalized indole ... See more keywords
An Expedient Dehomologative Annulation Synthesis of Pyrazole‐4‐Azetone Under Mild Condition
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70095
Abstract: A mild and efficient method has been developed for the synthesis of pyrazole‐4‐azetones from pyrazole‐4‐carbazaldehyde and 4‐amino‐thiazole under mild conditions. Herein, we represent the first report that enables access directly to the core structure of… read more here.
Keywords: synthesis pyrazole; dehomologative annulation; pyrazole; pyrazole azetone ... See more keywords
Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.04.011
Abstract: A new series of pyrazole derivatives was prepared in this work, including pyrazolopyrimidines, pyrazolotriazines, pyrazolylthienopyridines, and 2-(pyrazolylamino)thiazol-4-ones, utilizing 3-amino-5-methyl-1H-pyrazole as a synthetic precursor. Their in vitro anticancer activity was tested on hepatocellular carcinoma cell line,… read more here.
Keywords: hepatocellular carcinoma; molecular modeling; pyrazole; dna ... See more keywords
Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102982
Abstract: The reactions between 5-substituted pyrazolidine-3-ones, aldehydes, and methyl methacrylate provided tetrahydropyrazolo[1,2-a]pyrazole-1-carboxylates as mixtures of syn- and anti-diastereomers. Testing for inhibition of dihydroorotate dehydrogenase of Plasmodium falciparum (PfDHODH) revealed high activity of some anti-isomers of the… read more here.
Keywords: pyrazolo pyrazole; pyrazole; pyrazole carboxylates; plasmodium falciparum ... See more keywords
Electrochemical study of dibenzo-xanthene and dihydrobenzochromono pyrazole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.134990
Abstract: Abstract The electrochemical reduction of 9 substituted aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones (DBXT) and 10 substituted 3-methyl-1,4-diphenyl-1,4-dihydrobenzo [6,7]chromeno[2,3-c]pyrazole-5,10 diones (DCPD) in water/DMF mixture (30/70 v/v) has been studied by cyclic voltammetry, choronoamperometry and differential pulse voltammetry at a glassy… read more here.
Keywords: electrochemical reduction; dbxt derivatives; pyrazole; dibenzo xanthene ... See more keywords
Synthesis and biological studies of ruthenium, rhodium and iridium metal complexes with pyrazole-based ligands displaying unpredicted bonding modes
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.03.037
Abstract: Abstract A series of new mono, di thienyl pyrazole (L1) and bridged furyl pyrazole (L2) complexes of arene ruthenium, rhodium and iridium {arene = benzene, p-cymene and Cp∗} have been synthesized and characterized by spectroscopic techniques. The… read more here.
Keywords: ruthenium rhodium; pyrazole; benzene cymene; arene benzene ... See more keywords
Synthesis, crystal structure, characterization and antifungal activity of 3,4-diaryl-1H-Pyrazoles derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.07.106
Abstract: Abstract A series of 3,4-diaryl- 1H -pyrazoles derivatives were designed and synthesized by the reaction of 3-heteroarylchromones and 3-phenylchromones with hydrazine hydrate in good yields. All of those compounds were characterized by 1 H NMR,… read more here.
Keywords: diaryl pyrazoles; antifungal activity; pyrazoles derivatives; pyrazole ... See more keywords
Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128966
Abstract: Abstract A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11 were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All newly designed adamantane derivates were… read more here.
Keywords: pyrazole; study; molecular docking; ic50 ... See more keywords
Ruthenium Pyrazole Complexes: A Family of Highly Active Metallodrugs for Photoactivated Chemotherapy.
Sign Up to like & getrecommendations! Published in 2024 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c03716
Abstract: Ruthenium complexes bearing bis pyrazole (pzH) ligands, cis-[Ru(bpy)2(R-pzH)2]2+ (bpy = 2,2'-bipyridine, R = -H, -Cl), were examined as photoactivated anticancer prodrugs. A dicationic pyrazole complex deprotonated to give monocationic pyrazole-pyrazolate complexes, cis-[Ru(bpy)2(R-pz-)(R-pzH)]+, in an aqueous… read more here.
Keywords: ruthenium; pyrazole complexes; cis bpy; ruthenium pyrazole ... See more keywords
Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00050
Abstract: Developing selective inhibitors for Janus kinase 1 (JAK1) is a significant focus for improving the efficacy and alleviating the adverse effects in treating immune-inflammatory diseases. Herein, we report the discovery of a series of C-5… read more here.
Keywords: pyrazole; inhibitors janus; selective inhibitors; discovery pyrazole ... See more keywords