An Efficient and Facile Synthesis of Functionalized Indole-3-yl Pyrazole Derivatives Starting from 3-Cyanoacetylindole
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2654
Abstract: The versatile hitherto reported 3-(1H-indol-3-yl)-1H-pyrazol-5-amine () was synthesized by the reaction of 3-cyanoacetylindole () with hydrazine hydrate in refluxing ethanol and used as a key intermediate for the synthesis of novel pyrazolo[1,5-a]pyrimidines via its reactions… read more here.
Keywords: pyrazole; synthesis functionalized; facile synthesis; functionalized indole ... See more keywords
Targeting hepatocellular carcinoma: Synthesis of new pyrazole-based derivatives, biological evaluation, DNA binding, and molecular modeling studies.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.04.011
Abstract: A new series of pyrazole derivatives was prepared in this work, including pyrazolopyrimidines, pyrazolotriazines, pyrazolylthienopyridines, and 2-(pyrazolylamino)thiazol-4-ones, utilizing 3-amino-5-methyl-1H-pyrazole as a synthetic precursor. Their in vitro anticancer activity was tested on hepatocellular carcinoma cell line,… read more here.
Keywords: hepatocellular carcinoma; molecular modeling; pyrazole; dna ... See more keywords
Tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylates as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102982
Abstract: The reactions between 5-substituted pyrazolidine-3-ones, aldehydes, and methyl methacrylate provided tetrahydropyrazolo[1,2-a]pyrazole-1-carboxylates as mixtures of syn- and anti-diastereomers. Testing for inhibition of dihydroorotate dehydrogenase of Plasmodium falciparum (PfDHODH) revealed high activity of some anti-isomers of the… read more here.
Keywords: pyrazolo pyrazole; pyrazole; pyrazole carboxylates; plasmodium falciparum ... See more keywords
Electrochemical study of dibenzo-xanthene and dihydrobenzochromono pyrazole derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.134990
Abstract: Abstract The electrochemical reduction of 9 substituted aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones (DBXT) and 10 substituted 3-methyl-1,4-diphenyl-1,4-dihydrobenzo [6,7]chromeno[2,3-c]pyrazole-5,10 diones (DCPD) in water/DMF mixture (30/70 v/v) has been studied by cyclic voltammetry, choronoamperometry and differential pulse voltammetry at a glassy… read more here.
Keywords: electrochemical reduction; dbxt derivatives; pyrazole; dibenzo xanthene ... See more keywords
Synthesis and biological studies of ruthenium, rhodium and iridium metal complexes with pyrazole-based ligands displaying unpredicted bonding modes
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.03.037
Abstract: Abstract A series of new mono, di thienyl pyrazole (L1) and bridged furyl pyrazole (L2) complexes of arene ruthenium, rhodium and iridium {arene = benzene, p-cymene and Cp∗} have been synthesized and characterized by spectroscopic techniques. The… read more here.
Keywords: ruthenium rhodium; pyrazole; benzene cymene; arene benzene ... See more keywords
Synthesis, crystal structure, characterization and antifungal activity of 3,4-diaryl-1H-Pyrazoles derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2017.07.106
Abstract: Abstract A series of 3,4-diaryl- 1H -pyrazoles derivatives were designed and synthesized by the reaction of 3-heteroarylchromones and 3-phenylchromones with hydrazine hydrate in good yields. All of those compounds were characterized by 1 H NMR,… read more here.
Keywords: diaryl pyrazoles; antifungal activity; pyrazoles derivatives; pyrazole ... See more keywords
Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128966
Abstract: Abstract A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11 were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All newly designed adamantane derivates were… read more here.
Keywords: pyrazole; study; molecular docking; ic50 ... See more keywords
Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00050
Abstract: Developing selective inhibitors for Janus kinase 1 (JAK1) is a significant focus for improving the efficacy and alleviating the adverse effects in treating immune-inflammatory diseases. Herein, we report the discovery of a series of C-5… read more here.
Keywords: pyrazole; inhibitors janus; selective inhibitors; discovery pyrazole ... See more keywords
Asymmetric synthesis of atropisomeric pyrazole via an enantioselective reaction of azonaphthalene with pyrazolone.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc06360a
Abstract: The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68-99%) with excellent enantioselectivities (83-98% ee) by utilizing chiral… read more here.
Keywords: azonaphthalene pyrazolone; asymmetric synthesis; pyrazole; reaction azonaphthalene ... See more keywords
Triarylpyrazole Derivatives as Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation "Pyrazole Derivatives as Anticancer Agent".
Sign Up to like & getrecommendations! Published in 2021 at "Drug research"
DOI: 10.1055/a-1498-1714
Abstract: BACKGROUND During the last recent years, several anti-cancer agents were introduced for the treatment of diverse kinds of cancer. Despite their potential in the treatment of cancer, drug resistance and adverse toxicity such as peripheral… read more here.
Keywords: pyrazole; derivatives anticancer; evaluation pyrazole; pyrazole derivatives ... See more keywords
Cu(II) coordination polymers stabilized by pyridine-2,6-dicarboxylate anion and pyrazole derivatives through ligand hydrolysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2018.1501562
Abstract: Abstract 2,6-Pyridinedicarbonyldichloride (PDD) was treated with pyrazole, 3-methylpyrazole, and 3,5-dimethylpyrazole in the presence of trimethylamine at room temperature. Reactions afforded 2,6-bis(pyrazolyl-1-carbonyl)pyridine (1), 2,6-bis(3-methylpyrazolyl-1-carbonyl)pyridine (2) and 2,6-bis(3,5-dimethylpyrazolyl-1-carbonyl)pyridine (3). 1-3 were treated with copper ion under ambient… read more here.
Keywords: coordination; pyrazole; carbonyl pyridine; coordination polymers ... See more keywords