Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.
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DOI: 10.1021/acsmedchemlett.2c00116
Abstract: G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson's disease, as well as for some forms of cancer, and… read more here.
Keywords: lrrk2 kinase; pyrazole biaryl; kinase inhibitors; kinase ... See more keywords