Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro
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DOI: 10.3390/biology11060930
Abstract: Simple Summary Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective… read more here.
Keywords: cell; pyrazole derivative; tpz; thieno pyrazole ... See more keywords
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics
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DOI: 10.3390/cimb44110361
Abstract: Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern. Multiple drug resistance has also emerged in several… read more here.
Keywords: pyrazole; kit; pyrazole derivative; raf cyp17 ... See more keywords