Synthesis and biological evaluation of 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-01951-w
Abstract: Series of novel 3-(2,4-dichlorophenoxymethyl)-1-phenyl-1H-pyrazole derivatives with various substituents at positions 4 and 5 were synthesized. Antitumor activity of all the synthesized compounds was evaluated by using SRB assay on four cell lines: lung carcinoma (A549),… read more here.
Keywords: pyrazole derivatives; cell lines; phenyl pyrazole; dichlorophenoxymethyl phenyl ... See more keywords
Synthesis, in vitro evaluation and molecular docking of new pyrazole derivatives bearing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety as potent antibacterial agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02086-8
Abstract: In the current study, a new series of pyrazole derivatives 4a – d , 5a – d and 6a – d possessing 1,5,10,10a-tetrahydrobenzo[ g ]quinoline-3-carbonitrile moiety were synthesized by treating chalcones ( 3a – d… read more here.
Keywords: pyrazole derivatives; moiety; quinoline carbonitrile; 10a tetrahydrobenzo ... See more keywords
Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103470
Abstract: Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C3H3N2H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain… read more here.
Keywords: developments pyrazole; overview recent; anticancer agent; derivatives anticancer ... See more keywords
Synthesis, characterization and molecular docking studies of substituted 4-coumarinylpyrano[2,3-c]pyrazole derivatives as potent antibacterial and anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.021
Abstract: A green, eco-friendly and efficient protocol has been developed and synthesized a series of coumarin based pyrano[2,3-c]pyrazole derivatives (3) by multi-component reaction (MCR). Unexpected 3-coumarinyl-3-pyrazolylpropanoic acids (4) have been isolated by the reaction of compound… read more here.
Keywords: anti inflammatory; pyrazole derivatives; characterization molecular; molecular docking ... See more keywords
Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.098
Abstract: A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell… read more here.
Keywords: induction effects; dna damage; bis pyrazole; pyrazole derivatives ... See more keywords
DABCO catalyzed rapid one-pot synthesis of 1,4-dihydropyrano [2,3-c] pyrazole derivatives in aqueous media
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DOI: 10.1016/j.jscs.2015.06.010
Abstract: Abstract A simple and efficient protocol is developed for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives by a one pot, four component reaction of ethylacetoacetate, hydrazine hydrate, malanonitrile and various aldehydes in the presence of a catalytic… read more here.
Keywords: pyrazole derivatives; dihydropyrano pyrazole; synthesis dihydropyrano; one pot ... See more keywords
Polyvinyl amine as a modified and grafted shell for Fe3O4 nanoparticles: As a strong solid base catalyst for the synthesis of various dihydropyrano[2,3-c]pyrazole derivatives and the Knoevenagel condensation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2018.05.008
Abstract: Abstract In this work, we reported one-step deposition of polyacrylamide on nano-magnetite surface via a simple and in situ polymerization of acryl amide to form n-Fe3O4/PAM nanocomposite. The amide (–CONH2) groups could be converted easily… read more here.
Keywords: base catalyst; catalyst; various dihydropyrano; pyrazole derivatives ... See more keywords
Pyrazole derivatives as environmental benign acid corrosion inhibitors for mild steel: Experimental and computational studies
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DOI: 10.1016/j.molliq.2019.111943
Abstract: Abstract Four industrially relevant pyrazole derivatives (PYRs) differing in their nature of substituents were synthesized by an eco-friendly one-pot multicomponent reaction (MCR), and their acid corrosion inhibition was studied for mild steel using experimental and… read more here.
Keywords: mild steel; inhibition; pyrazole derivatives; experimental computational ... See more keywords
Study of the solvation process of some pyrazole derivatives in three different solvents by solution calorimetry and IR spectroscopy: Unravelling solute-solvent interactions
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DOI: 10.1016/j.molliq.2020.113275
Abstract: Abstract The study of the relationship between intermolecular interactions present in the solvation process and the magnitude of thermodynamic properties is extended from imidazole to pyrazole derivatives. The enthalpies of solution of pyrazole, 3,5-dimethylpyrazole and… read more here.
Keywords: pyrazole derivatives; solvation; solvation process; spectroscopy ... See more keywords
Copper(II)-catalyzed-α-C(sp3)-H activation of cyclic amines: A simple and efficient strategy for the synthesis of fused pyrazole derivatives
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DOI: 10.1016/j.tetlet.2018.10.017
Abstract: Abstract In this paper, we have described a simple and efficient strategy for the synthesis of fused pyrazole derivatives. The key steps of our strategy involves hydroamination, copper-catalyzed cross dehydrogenative coupling (CDC) followed by aromatization… read more here.
Keywords: pyrazole derivatives; fused pyrazole; strategy; synthesis fused ... See more keywords
Discovery of Novel Pyrazole Derivatives with Improved Crop Safety as 4-Hydroxyphenylpyruvate Dioxygenase-Targeted Herbicides.
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DOI: 10.1021/acs.jafc.2c07551
Abstract: As one of the essential herbicide targets, 4-hydroxyphenylpyruvate dioxygenase (HPPD) has recently been typically used to produce potent new herbicides. In continuation with the previous work, several pyrazole derivatives comprising a benzoyl scaffold were designed… read more here.
Keywords: pyrazole derivatives; hydroxyphenylpyruvate dioxygenase; crop safety;