Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors
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DOI: 10.1002/ardp.202000116
Abstract: In continuation of our previous work on cancer and inflammation, 15 novel pyrazole–pyrazoline hybrids (WSPP1–15) were synthesized and fully characterized. The formation of the pyrazoline ring was confirmed by the appearance of three doublets of… read more here.
Keywords: pyrazole pyrazoline; pyrazoline; pyrazoline hybrids; cox ... See more keywords
In silico studies, nitric oxide, and cholinesterases inhibition activities of pyrazole and pyrazoline analogs of diarylpentanoids
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DOI: 10.1002/ardp.202000161
Abstract: A new series of pyrazole, phenylpyrazole, and pyrazoline analogs of diarylpentanoids (excluding compounds 3a, 4a, 5a, and 5b) was pan‐assay interference compounds‐filtered and synthesized via the reaction of diarylpentanoids with hydrazine monohydrate and phenylhydrazine. Each… read more here.
Keywords: analogs diarylpentanoids; silico studies; pyrazole pyrazoline; studies nitric ... See more keywords
Pyrazole/pyrazoline as an excellent pharmacophore in the design of carbonic anhydrase inhibitors (2018–2022)
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DOI: 10.1002/ardp.202200562
Abstract: Carbonic anhydrase (CA) is a metalloenzyme that catalyzes the interconversion between carbon dioxide and water and dissociated ions of carbonic acid. In addition, CA performs various other functions in animals and plants, depending on the… read more here.
Keywords: pyrazoline excellent; design; carbonic anhydrase; pyrazole pyrazoline ... See more keywords