Design and synthesis of pyrazole–pyrazoline hybrids as cancer‐associated selective COX‐2 inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000116
Abstract: In continuation of our previous work on cancer and inflammation, 15 novel pyrazole–pyrazoline hybrids (WSPP1–15) were synthesized and fully characterized. The formation of the pyrazoline ring was confirmed by the appearance of three doublets of… read more here.
Keywords: pyrazole pyrazoline; pyrazoline; pyrazoline hybrids; cox ... See more keywords
Regio- and stereoselective route to bis-[3-methyl-1,1′,4′-triaryl-5-oxo-spiro-pyrazoline-4,5′-pyrazoline] derivatives via 1,3-dipolar cycloaddition under sonication
Sign Up to like & getrecommendations! Published in 2018 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.05.016
Abstract: Abstract Bis-[3-methyl-1,1′,4′-triaryl-5-oxo-spiro-pyrazoline-4,5′-pyrazoline] derivatives are synthesized regio- and stereoselectively via 1,3-dipolar cycloaddition of the bis-hydrazonoyl chlorides with 4-arylidenepyrazol-5-one derivatives. The cycloaddition route is optimized under both ultrasonic irradiation and conventional heating modes. The regio- and stereoselectivity… read more here.
Keywords: bis methyl; pyrazoline; methyl triaryl; bis ... See more keywords
Selective fluorometric “Turn-off” sensing for Hg2+ with pyrazoline compound and its application in real water sample analysis
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.119288
Abstract: Abstract In this study, a new pyrazoline derivative (4-(3-phenyl-3a,4-dihydroindeno[1,2-c]pyrazol-2(3H)-yl)benzenesulfonamide, K1) was described as fluorescent probe for fluorometric detection of Hg2+. This fluorescence probe had a high selectivity only toward Hg2+ ion in the 19 metal… read more here.
Keywords: sample; hg2; fluorescence; pyrazoline ... See more keywords
Synthesis of some substituted furo[3,2-g]chromeno[2,3-c]pyrazole and pyrazoline derivatives from 5-hydroxybergapten and 5-hydroxyisopimpinellin as EGFR and VEGFR-2 kinase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217070258
Abstract: A series of substituted 7H-furo[3,2-g]chromen-7-one and furo[3,2-g]chromeno[2,3-c]pyrazole derivatives (2–9) were synthesized by using 5-hydroxy-4-methoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxybergapten) and 5-hydroxy-4,9-dimethoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxyisopimpinellin) (1) as starting materials. Compound 1 reacted with amino acid esters to give the corresponding 5-N-amino acid… read more here.
Keywords: substituted furo; furo chromeno; egfr vegfr; pyrazoline ... See more keywords
Design, Synthesis, In Silico ADMET Studies and Anticancer Activity of Some New Pyrazoline and Benzodioxole Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2021.7119
Abstract: A new series of 2-pyrazoline derivatives starting from substituted benzodioxole chalcones were designed and synthesized. IR and 1H NMR spectral data and elemental analysis were used to characterize the structures of the synthesized compounds. The… read more here.
Keywords: design synthesis; anticancer activity; silico admet; activity ... See more keywords