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1
Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21976
Abstract: We herein report a new series of indole‐tethered pyrazoline derivatives as potent anticancer agents. A total of 12 compounds were designed and synthesized by conventional as well as microwave‐irradiated synthesis methods. The latter method results…
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Keywords:
anticancer agents;
synthesis;
topoisomerase;
indole tethered ... See more keywords
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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1838-5
Abstract: In the present study, synthesis and characterization of pyrazoline derivatives integrated with sulfonamide scaffold have been performed. The characterization of the molecules was done by elemental analysis, ultraviolet–visible, infrared, nuclear magnetic resonance (NMR), and mass…
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Keywords:
pyrazoline derivatives;
crystal structure;
activity;
synthesis ... See more keywords
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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2081-9
Abstract: A series of pyrazoline derivatives were synthesized and their structures have been characterized by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. The novel compounds were designed as Mycobacterium tuberculosis shikimate kinase (MtSK)…
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Keywords:
design synthesis;
molecular modeling;
pyrazoline derivatives;
shikimate kinase ... See more keywords
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1
Published in 2017 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-017-1327-x
Abstract: Abstract1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy…
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Keywords:
hbox hbox;
hbox cecl;
pyrazoline derivatives;
hbox ... See more keywords
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Published in 2017 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2015.1099553
Abstract: ABSTRACT Pyrazolines derivatives are nitrogen-containing heterocyclic compound, which exhibit the broad spectrum of biological activities such as antibacterial, antifungal, antiprotozoal, and anti-inflammatory. The optimized geometry, frequency, and intensity of vibrational bands of these compounds are…
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Keywords:
vibrational spectra;
molecular structures;
study;
pyrazoline derivatives ... See more keywords
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Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217070258
Abstract: A series of substituted 7H-furo[3,2-g]chromen-7-one and furo[3,2-g]chromeno[2,3-c]pyrazole derivatives (2–9) were synthesized by using 5-hydroxy-4-methoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxybergapten) and 5-hydroxy-4,9-dimethoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxyisopimpinellin) (1) as starting materials. Compound 1 reacted with amino acid esters to give the corresponding 5-N-amino acid…
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Keywords:
substituted furo;
furo chromeno;
egfr vegfr;
pyrazoline ... See more keywords
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Published in 2018 at "Crystals"
DOI: 10.3390/cryst8120467
Abstract: Two novel 1,3,5-trisubstituted pyrazoline derivatives—1-acetyl-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-pyrazoline (2a) and 1-(4-nitrophenyl)-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphtyl)-pyrazoline (2b)—were synthesized and their structures were determined by single crystal X-ray crystallography. Both of the two crystals exhibit twisted structures due to the large dihedral angles between…
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Keywords:
novel trisubstituted;
pyrazoline derivatives;
trisubstituted pyrazoline;
properties two ... See more keywords
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2
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073497
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene, which is involved in the RAS/MAPK cell signaling transduction process. SHP2 has been shown…
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Keywords:
vitro vivo;
toward treatment;
series;
pyrazoline derivatives ... See more keywords