Synthesis, biological evaluation, and in silico studies of indole‐tethered pyrazoline derivatives as anticancer agents targeting topoisomerase IIα
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21976
Abstract: We herein report a new series of indole‐tethered pyrazoline derivatives as potent anticancer agents. A total of 12 compounds were designed and synthesized by conventional as well as microwave‐irradiated synthesis methods. The latter method results… read more here.
Keywords: anticancer agents; synthesis; topoisomerase; indole tethered ... See more keywords
Synthesis, spectral, biological activity, and crystal structure evaluation of novel pyrazoline derivatives having sulfonamide moiety
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-1838-5
Abstract: In the present study, synthesis and characterization of pyrazoline derivatives integrated with sulfonamide scaffold have been performed. The characterization of the molecules was done by elemental analysis, ultraviolet–visible, infrared, nuclear magnetic resonance (NMR), and mass… read more here.
Keywords: pyrazoline derivatives; crystal structure; activity; synthesis ... See more keywords
Design, synthesis, molecular modeling, and ADMET studies of some pyrazoline derivatives as shikimate kinase inhibitors
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DOI: 10.1007/s00044-017-2081-9
Abstract: A series of pyrazoline derivatives were synthesized and their structures have been characterized by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. The novel compounds were designed as Mycobacterium tuberculosis shikimate kinase (MtSK)… read more here.
Keywords: design synthesis; molecular modeling; pyrazoline derivatives; shikimate kinase ... See more keywords
An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by $$\hbox {CeCl}_{3} \cdot 7\hbox {H}_{2}\hbox {O}$$CeCl3·7H2O
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DOI: 10.1007/s12039-017-1327-x
Abstract: Abstract1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy… read more here.
Keywords: hbox hbox; hbox cecl; pyrazoline derivatives; hbox ... See more keywords
Molecular Structures, Vibrational Spectra, Electronic Properties, and Molecular Docking of Two Pyrazoline Derivatives Containing 1-Carboxamide and 1-Carbothioamide: A Comparative Study
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DOI: 10.1080/10406638.2015.1099553
Abstract: ABSTRACT Pyrazolines derivatives are nitrogen-containing heterocyclic compound, which exhibit the broad spectrum of biological activities such as antibacterial, antifungal, antiprotozoal, and anti-inflammatory. The optimized geometry, frequency, and intensity of vibrational bands of these compounds are… read more here.
Keywords: vibrational spectra; molecular structures; study; pyrazoline derivatives ... See more keywords
Synthesis of some substituted furo[3,2-g]chromeno[2,3-c]pyrazole and pyrazoline derivatives from 5-hydroxybergapten and 5-hydroxyisopimpinellin as EGFR and VEGFR-2 kinase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217070258
Abstract: A series of substituted 7H-furo[3,2-g]chromen-7-one and furo[3,2-g]chromeno[2,3-c]pyrazole derivatives (2–9) were synthesized by using 5-hydroxy-4-methoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxybergapten) and 5-hydroxy-4,9-dimethoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxyisopimpinellin) (1) as starting materials. Compound 1 reacted with amino acid esters to give the corresponding 5-N-amino acid… read more here.
Keywords: substituted furo; furo chromeno; egfr vegfr; pyrazoline ... See more keywords
Crystal Structures and Optical Properties of Two Novel 1,3,5-Trisubstituted Pyrazoline Derivatives
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DOI: 10.3390/cryst8120467
Abstract: Two novel 1,3,5-trisubstituted pyrazoline derivatives—1-acetyl-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-pyrazoline (2a) and 1-(4-nitrophenyl)-3-(4-methoxyphenyl)-5-(6-methoxy-2-naphtyl)-pyrazoline (2b)—were synthesized and their structures were determined by single crystal X-ray crystallography. Both of the two crystals exhibit twisted structures due to the large dihedral angles between… read more here.
Keywords: novel trisubstituted; pyrazoline derivatives; trisubstituted pyrazoline; properties two ... See more keywords
Toward a Treatment of Cancer: Design and In Vitro/In Vivo Evaluation of Uncharged Pyrazoline Derivatives as a Series of Novel SHP2 Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073497
Abstract: Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene, which is involved in the RAS/MAPK cell signaling transduction process. SHP2 has been shown… read more here.
Keywords: vitro vivo; toward treatment; series; pyrazoline derivatives ... See more keywords