Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors.
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DOI: 10.1016/j.bioorg.2020.104322
Abstract: Celecoxib, is a selective cyclooxygenase-2 (COX2) inhibitor with a 1,5-diaryl pyrazole scaffold. Celecoxib has a better safety profile compared to other COX2 inhibitors having side effects of systemic hypertension and thromboembolic complications. This may be… read more here.
Keywords: pyrazolines novel; pde5 inhibitors; pde5; discovery trisubstituted ... See more keywords