A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents
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DOI: 10.1007/s00044-020-02635-z
Abstract: A novel series of 5-amino-6-substituted-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]selenolo[3,2-e]pyrazines (3a–e) was synthesized by the reaction of the chloro pyrazolo[3,4-b]pyrazine carbonitrile 1 with selenium element in the presence of sodium borohydride and ethanol, followed by the reaction with α-halo alkylating… read more here.
Keywords: pyrazolo; selenolo pyrazine; synthesis; pyrazolo selenolo ... See more keywords
Synthesis and discovery of pyrazolo-pyridine analogs as inflammation medications through pro- and anti-inflammatory cytokine and COX-2 inhibition assessments.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103484
Abstract: This article briefs about the efforts taken to synthesis, characterize and develop (E)-5-methyl-2-phenyl-3-(thiophen-2-yl)-7-(thiophen-2-ylmethylene)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine and their analogs. In the two-step reaction, the first step is the synthesis of (3Z,5E)-1-methyl-3,5-bis(thiophen-2-ylmethylene)piperidin-4-one derivatives (3a-l) by stirring the mixture of… read more here.
Keywords: anti inflammatory; pyrazolo pyridine; cox inhibition; pyrazolo ... See more keywords
SnCl2-catalyzed synthesis of dihydro-5H-benzo[f]pyrazolo[3,4-b]quinoline and dihydroindeno[2,1-b]pyrazolo[4,3-e]pyridine with high fluorescence and their photophysical properties
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DOI: 10.1039/c7nj03654j
Abstract: A series of high-performance chromophores, namely pyrazoloquinoline- and pyrazolopyridine-based derivatives bearing donor–acceptor (D–A) substituent groups on the phenyl ring, was synthesized by a mild reaction. Photophysical studies, including spectral analysis and single crystal X-ray diffraction,… read more here.
Keywords: pyrazolo; pyridine; fluorescence; sncl2 catalyzed ... See more keywords
Facile synthesis and characterization of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one and pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine incorporating 1,3-diarylpyrazole moiety
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1468911
Abstract: Abstract 4-(3-(4-Hydroxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-di hydro-pyridine-3-carbonitrile (1) reacted with ethyl chloroacetate (2) in ethanolic sodium acetate solution to yield the corresponding ethyl (3-cyanopyridin-2-ylsulphanyl)acetate derivative 3. Intramolecular cyclization of compound 3 was achieved by its heating in DMF containing… read more here.
Keywords: pyrido pyrazolo; pyrimidin one; pyrido thieno; pyrazolo ... See more keywords
Development of pyrazolo[1,5-a]pyrimidine-based antibacterial agents
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DOI: 10.1080/00397911.2023.2209815
Abstract: Abstract In the present study, a facile method was adopted to efficiently prepare new pyrazolo[1,5-a]pyrimidin-2-amines linked to arene units in good to excellent yields. A mixture of acetophenones and DMF-DMA was heated at 120 oC… read more here.
Keywords: antibacterial activity; based antibacterial; pyrazolo pyrimidine; pyrazolo ... See more keywords
Facile Catalyst-Free Synthesis of New Functionalized 1H-Pyrazolo[1,2-b]phthalazines
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DOI: 10.1134/s1070363218120216
Abstract: Some new derivatives of 3-amino-1-aryl-N-butyl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]- phthalazine-2-carboxamide are synthesized via in situ Knoevenagel condensation of aromatic aldehydes with N-butyl-2-cyanoacetamide, which leads to 3-aryl-N-butyl-2-cyanoacrylamides. This is followed by the reaction with phthalhydrazide upon refluxing in ethanol under… read more here.
Keywords: free synthesis; synthesis new; new functionalized; facile catalyst ... See more keywords
Synthesis, Characterization and Biological Application of Pyrazolo[1,5-a]pyrimidine Based Organometallic Re(I) Complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2020.6017
Abstract: The neutral rhenium(I) complexes (I-VI) of type [ReCl(CO)3Ln-] where L1 = 7-phenyl-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine, L2 = 7-(4-bromophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimi- dine, L3 = 7-(4-chlorophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine, L4 = 7-(2-chlorophenyl) -5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine, L5 = 7-(4-methoxyphenyl)-5-(pyridin-2-yl)pyrazolo [1,5-a]pyrimidine, L6 = 5-(pyridin-2-yl)-7-(p-tolyl)pyrazolo[1,5-a]pyrimidine were synthesized and characterized by… read more here.
Keywords: pyrazolo; pyridin pyrazolo; pyrazolo pyrimidine; synthesis characterization ... See more keywords
A new and efficient method for the synthesis of pyrazolo[3,4-d] pyrimidines catalyzed by iodine
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DOI: 10.24200/sci.2018.21137
Abstract: Fully substituents new pyrazolo[3,4-d]pyrimidines were synthesized. The synthesis starts with cyanomethylphenylketone that reacts with phenyl hydrazine to give the corresponding aminopyrazole. The latter undergoes a cyclocondensation with an N,N'-bis(arylmethylidene)arylmethane yielding the final product. Both synthetic… read more here.
Keywords: efficient method; new efficient; pyrazolo pyrimidines; pyrazolo ... See more keywords
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor
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DOI: 10.3390/cancers11060848
Abstract: Overexpression of P-glycoprotein (P-gp) and other ATP-binding cassette (ABC) transporters in multidrug resistant (MDR) cancer cells is responsible for the reduction of intracellular drug accumulation, thus decreasing the efficacy of chemotherapeutics. P-gp is also found… read more here.
Keywords: treatment; glycoprotein; new strategy; pyrazolo ... See more keywords
Synthesis and Structure–Activity Relationships for the Anti-Mycobacterial Activity of 3-Phenyl-N-(Pyridin-2-ylmethyl)Pyrazolo[1,5-a]Pyrimidin-7-Amines
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DOI: 10.3390/ph15091125
Abstract: Pyrazolo[1,5-a]pyrimidines have been reported as potent inhibitors of mycobacterial ATP synthase for the treatment of Mycobacterium tuberculosis (M.tb). In this work, we report the design and synthesis of approximately 70 novel 3,5-diphenyl-N-(pyridin-2-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amines and their comprehensive… read more here.
Keywords: pyridin ylmethyl; pyrazolo; activity; pyrazolo pyrimidin ... See more keywords
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
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DOI: 10.3390/pharmaceutics15020453
Abstract: The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual inhibitors. Herein,… read more here.
Keywords: cell; kinase inhibitors; pyrazolo; tyrosine kinase ... See more keywords