Novel pyrazolo[3,4‐b]pyridine derivatives: Synthesis, structure–activity relationship studies, and regulation of the AMPK/70S6K pathway
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100465
Abstract: A series of novel pyrazolo[3,4‐b]pyridine derivatives were designed, synthesized, and biologically evaluated for anti‐lung cancer activity. Structure–activity relationship and AutoGPA models were constructed based on the in vitro antiproliferative potency of the compounds against a… read more here.
Keywords: novel pyrazolo; structure activity; pyrazolo pyridine; pyridine derivatives ... See more keywords
Harnessing cascade Suzuki‐cyclization reactions of pyrazolo[3,4‐b]pyridine for the synthesis of tetracyclic fused heteroaromatics
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601242
Abstract: Numerous procedures have been described for the functionalization of pyrazolo[3,4-b]pyridine, mainly nucleophilic substitutions on C-4 position and esterifications/amidations on C-5 position. Thus, we report herein a robust, easy to implement protocol for the Suzuki cross-coupling… read more here.
Keywords: suzuki cyclization; pyrazolo pyridine; harnessing cascade; suzuki ... See more keywords
Synthesis and discovery of pyrazolo-pyridine analogs as inflammation medications through pro- and anti-inflammatory cytokine and COX-2 inhibition assessments.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103484
Abstract: This article briefs about the efforts taken to synthesis, characterize and develop (E)-5-methyl-2-phenyl-3-(thiophen-2-yl)-7-(thiophen-2-ylmethylene)-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine and their analogs. In the two-step reaction, the first step is the synthesis of (3Z,5E)-1-methyl-3,5-bis(thiophen-2-ylmethylene)piperidin-4-one derivatives (3a-l) by stirring the mixture of… read more here.
Keywords: anti inflammatory; pyrazolo pyridine; cox inhibition; pyrazolo ... See more keywords
Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.057
Abstract: c-Met was emerging as an attractive target for cancer-targeted therapy because deregulation of c-Met has been observed in multiple tumor types. A series of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives were designed, synthesized and evaluated for their enzymatic inhibitory… read more here.
Keywords: pyridine derivatives; design; tetrahydro pyrazolo; pyrazolo pyridine ... See more keywords
An Expedient Approach to Pyrazolo[3,4-b]pyridine-3-carboxamides via Palladium-Catalyzed Aminocarbonylation
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DOI: 10.1055/s-0037-1610783
Abstract: Pyrazolo[3,4-b]pyridine is a privileged scaffold found in many small drug molecules that possess a wide range of pharmacological properties. Efforts to further develop and exploit synthetic methodologies that permit the functionalization of this heterocyclic moiety… read more here.
Keywords: palladium catalyzed; pyridine; catalyzed aminocarbonylation; pyrazolo pyridine ... See more keywords
Advances in 4,6‐dimethyl-3-amino-3H-pyrazolo[3,4-b] pyridine-based and their annulated systems
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DOI: 10.1080/00397911.2020.1786126
Abstract: Abstract This review supply an inclusive survey of the recent progress in the chemistry of 4,6‐dimethyl-3-amino-3H-pyrazolo[3,4-b]pyridine concerning the synthesis and reactions and biological activity over the period from the year 1990 to the year 2020.… read more here.
Keywords: dimethyl amino; pyrazolo pyridine; advances dimethyl; amino pyrazolo ... See more keywords
Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2076674
Abstract: sABSTRACT TANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis.… read more here.
Keywords: tbk1; pyrazolo pyridine; tbk1 inhibitors; pyridine derivatives ... See more keywords