Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.037
Abstract: An efficient synthetic route for the synthesis of 2H-pyrazolo[4,3-c]pyridines, primarily varying by the substituents at the 2-, 4- and 6-positions, is described here. A Sonogashira-type cross-coupling reaction was employed to yield 3-alkynyl-1H-pyrazole-4-carbaldehydes, ethanones and propanones… read more here.
Keywords: anti mitotic; pyrazolo pyridines; synthesis anti; mitotic activity ... See more keywords
Application of Metal-Organic Frameworks with Sulfonic Acid Tags in the Synthesis of Pyrazolo[3,4-b]pyridines via a Cooperative Vinylogous Anomeric-Based Oxidation.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c01131
Abstract: Herein, we report the design and synthesis of Co-MOF-71/imidazole/SO3H as a novel porous catalyst with sulfonic acid tags. The structure and morphology of the catalyst were investigated using various techniques such as Fourier transform-infrared spectroscopy… read more here.
Keywords: spectroscopy; pyrazolo pyridines; sulfonic acid; acid tags ... See more keywords
Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02500
Abstract: A mechanistically distinctive copper-catalyzed radical annulation to valuable 2-(trifluoromethyl)pyrazolo[1,5-a]pyridines and their benzo analogues has been described for the first time. Notably, the newly developed complementary process allows the synthesis of 4- or 6-substituted target molecular… read more here.
Keywords: pyridines benzo; catalyzed radical; radical annulation; pyrazolo pyridines ... See more keywords
Synthesis of Fluorescent 1,7-Dipyridyl-bis-pyrazolo[3,4-b:4′,3′-e]pyridines: Design of Reversible Chemosensors for Nanomolar Detection of Cu2+
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00226
Abstract: An efficient access toward novel tridentate ligands based on 1,7-dipyridinyl-substituted bis-pyrazolo[3,4-b:4′,3′-e]pyridines (BPs) and their usefulness as fluorescent probes for cation detection is reported. The synthesis proceeds by a three-step sequence starting from 2-chloropyridine (1), all… read more here.
Keywords: fluorescent; pyrazolo pyridines; bis pyrazolo; detection ... See more keywords
One-step Synthesis of Cyanated Pyrazolo[1, 5-a]pyridines Utilizing N-Aminopyridines as 1,3-Dipole and Nitrogen Source
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00417a
Abstract: By utilizing the dual reactivity function of N-aminopyridinium ylides, we develop direct [3 + 2]-cycloadditions of N-aminopyridinium ylides and ynals to build pyrazolo[1, 5-a]pyridines core while introducing a cyano group.... read more here.
Keywords: pyridines utilizing; one step; synthesis cyanated; pyrazolo pyridines ... See more keywords
1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072237
Abstract: Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to… read more here.
Keywords: pyrazolo pyridines; pyridines synthesis; biomedical applications; synthesis biomedical ... See more keywords