Discovery of Novel Pyrazolo-Pyridone DCN1 Inhibitors Controlling Cullin Neddylation.
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DOI: 10.1021/acs.jmedchem.9b00410
Abstract: Chemical control of cullin neddylation is attracting increased attention based largely on the successes of the NEDD8-activating enzyme (E1) inhibitor Pevonedistat. Recently reported chemical probes enable selective and time-dependent inhibition of downstream members of the… read more here.
Keywords: pyrazolo pyridone; cullin neddylation; discovery novel; dcn1 ... See more keywords