Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105220
Abstract: Two series of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors were designed to restrict bioactive configuration of (E,Z)-vinylogous CA-4. All of the target compounds were synthesized and then evaluated for their in vitro antiproliferative activities against three… read more here.
Keywords: polymerization; polymerization inhibitors; pyrazolo pyrimidines; diaryl pyrazolo ... See more keywords
Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00077d
Abstract: The synthesis of a new series of 4-acylaminopyrazolo[3,4-d]pyrimidines active on the sigma-1 receptor (σ1R) is reported. Compounds were efficiently prepared using a two to three step process starting from commercially available 1H-pyrazolo[3,4-d]pyrimidin-4-amine. A SAR study… read more here.
Keywords: pyrimidines sigma; pyrazolo pyrimidines; ligands treatment; treatment pain ... See more keywords
Polyethylene glycol-400 Prompted An Efficient Synthesis of Thienyl Pyrazolo[1,5-a] pyrimidines as Microbial Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220304160938
Abstract: AIM The aim of this present work was to design and establish an efficient synthesis of new thienyl pyrazolo[1,5-a] pyrimidines using enviormental friendly reaction solvent. Further, the newly synthesized compounds were evaluated for antimicrobial activity.… read more here.
Keywords: reaction; synthesis; thienyl pyrazolo; thienyl ... See more keywords
A new and efficient method for the synthesis of pyrazolo[3,4-d] pyrimidines catalyzed by iodine
Sign Up to like & getrecommendations! Published in 2018 at "Scientia Iranica"
DOI: 10.24200/sci.2018.21137
Abstract: Fully substituents new pyrazolo[3,4-d]pyrimidines were synthesized. The synthesis starts with cyanomethylphenylketone that reacts with phenyl hydrazine to give the corresponding aminopyrazole. The latter undergoes a cyclocondensation with an N,N'-bis(arylmethylidene)arylmethane yielding the final product. Both synthetic… read more here.
Keywords: efficient method; new efficient; pyrazolo pyrimidines; pyrazolo ... See more keywords
Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020453
Abstract: The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual inhibitors. Herein,… read more here.
Keywords: cell; kinase inhibitors; pyrazolo; tyrosine kinase ... See more keywords