Development of Novel Anticancer Pyrazolopyrimidinones Targeting Glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Chemmedchem"
DOI: 10.1002/cmdc.202500337
Abstract: Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumor and is one of the most difficult types of brain cancer to treat with a high incidence of resistance to traditionally used… read more here.
Keywords: pyrazolo pyrimidinones; glioblastoma; gbm; cell ... See more keywords
Sulphonated graphene oxide catalyzed continuous flow synthesis of pyrazolo pyrimidinones, sildenafil and other PDE-5 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra08220e
Abstract: Sulphonated graphene oxide was used for cascade condensation and cyclization reactions towards accessing substituted pyrazolo pyrimidinones. Further, sulphonation and amination reactions were integrated through continuous flow chemistry to access PDE-5 inhibitors. Herein, we report a… read more here.
Keywords: synthesis; sulphonated graphene; continuous flow; graphene oxide ... See more keywords
Synthesis of triazole bridged N-glycosides of pyrazolo[1,5-a]pyrimidinones as anticancer agents and their in silico docking studies
Sign Up to like & getrecommendations! Published in 2024 at "RSC Advances"
DOI: 10.1039/d3ra06993a
Abstract: In the pursuit of novel therapeutic agents, we present a comprehensive study on the design, synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo[1,5-a]pyrimidinones, employing a microwave-assisted synthetic approach via ‘click… read more here.
Keywords: cancer; pyrazolo pyrimidinones; triazole bridged; glycosides pyrazolo ... See more keywords