Cyclization of pyrazolones: novel synthesis of pyrano, pyrido, pyrimido and spiropyrazole derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1423-y
Abstract: Depending on the reaction conditions, two alternative cyclizations are possible for [3 + 3] cyclocondensation of pyrazolone derivative 1a and ethyl cyanoacetate of type pyrano [2,3-c] pyrazol-6(1H)-one 2 and pyrano [2,3-c] pyrazol-4(1H)-one 3. Keeping of enaminic system… read more here.
Keywords: pyrazolone; cyclization; pyrano; pyrazolone derivative ... See more keywords
Luminescent properties of Zn complexes based on tetradentate N2O2-donor pyrazolone schiff bases
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2020.108626
Abstract: Abstract A nine new Zn(II) complex were synthesized based on a new Salen-type tetradentate N2O2 ligands derived from 1-phenyl-3-methyl-4-formyl-5-pyrazolone. Complexes have been characterized by single-crystal X-ray diffraction, ESI-mass spectroscopy, elemental analysis, IR spectroscopy and thermal… read more here.
Keywords: pyrazolone; luminescent properties; tetradentate n2o2; complexes based ... See more keywords
Novel copper(II) and palladium(II) complexes with 4-aroyl-5-pyrazolone ligands: Synthesis and characterization
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2019.05.026
Abstract: Abstract Novel bidentate 4-aroyl-5-pyrazolone ligands were synthesized and reacted with copper(II) and palladium(II) salts in 1:2 (metal:ligand) equimolar ratio leading to the formation of eight new coordination compounds. All synthesized compounds were characterized by FTIR,… read more here.
Keywords: copper; pyrazolone; palladium complexes; aroyl pyrazolone ... See more keywords
Pyrazole, pyrazolone and enaminonitrile pyrazole derivatives: Synthesis, characterization and potential in corrosion inhibition and antimicrobial applications
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2017.12.156
Abstract: Abstract Six pyrazole and pyrazolone derivatives namely: 3-amino-1-phenyl-5-pyrazolone (1), 3-amino-1-(2,4-dinitrophenyl)-5-pyrazolone (2), 1H-pyrazole-3,5-diamine-4-(2-phenyldiazenyl) (3), 1-phenyl pyrazole-3, 5-diamine, 4-[2-(4-methylphenyl) diazenyl] (4), 1H-pyrazole-3,5-diamine, 4-[2-(4-methylphenyl) diazenyl] (5), 5-amino-1,3–diphenyl-1H-pyrazolecarbonitrile (6) were synthesized and evaluated as corrosion inhibitors for copper alloy… read more here.
Keywords: corrosion inhibition; pyrazolone; corrosion; pyrazole diamine ... See more keywords
Catalytic and Multicomponent Reactions for Green Synthesis of Some Pyrazolone Compounds and Evaluation as Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03070
Abstract: A green synthetic approach and facile method was developed to produce pyrazole compounds (6a–d) by the reaction of ethyl acetoacetate (1), hydrazines (2a–d), and catalytic imidazole (3) in aqueous media. 4-Dicyanomethylene-2-pyrazoline-5-one derivatives (14a–d) were synthesized… read more here.
Keywords: catalytic multicomponent; pyrazoline one; multicomponent reactions; reactions green ... See more keywords
Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc01123e
Abstract: An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and… read more here.
Keywords: substituted pyrazolone; derivatives bearing; pyrazolone; construction alkenyl ... See more keywords
Catalytic asymmetric [3 + 2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00618a
Abstract: A catalytic asymmetric construction of the bispiro[pyrazolone-dihydropyrrole-oxindole] skeleton catalyzed by chiral DMAP-derived catalyst was successfully achieved by employing recently explored pyrazolone-derived MBH carbonate in high yields with excellent stereoselectivities. The proposed transition state indicated that… read more here.
Keywords: bispiro pyrazolone; dihydropyrrole oxindole; pyrazolone dihydropyrrole; construction bispiro ... See more keywords
Role of hydrazone substituents in determining the nuclearity and antibacterial activity of Zn(II) complexes with pyrazolone-based hydrazones.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt02430f
Abstract: Hydrazones and their metal derivatives are very important compounds in medicinal chemistry due to their reported variety of biological activities, such as antibacterial, antifungal and anticancer action. Five hydrazone-pyrazolone ligands H2Ln (n = 1-5) were… read more here.
Keywords: antibacterial activity; role hydrazone; hydrazone substituents; pyrazolone ... See more keywords
Pyrazolone-type compounds (part II): in vitro and in silico evaluation of antioxidant potential; structure–activity relationship
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra08280b
Abstract: The pyrazolone class comprises a variety of hybrid compounds displaying diverse biological actions. Although studied for decades, these compounds are still of interest due to their facile chemical transformations. In our previous work, we presented… read more here.
Keywords: type compounds; vitro silico; compounds part; pyrazolone type ... See more keywords
Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103316
Abstract: Small molecules targeting the PD-1/PD-L1 checkpoint are actively searched to complement the anticancer arsenal. Different molecular scaffolds have been reported, including phenyl-pyrazolone derivatives which potently inhibit binding of PD-L1 to PD-1. These molecules are structurally… read more here.
Keywords: aldehyde reactivity; reactivity; antioxidant properties; pyrazolone ... See more keywords
Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083491
Abstract: Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts as a scavenger of… read more here.
Keywords: targeted phenyl; novel targeted; antioxidant properties; pyrazolone ... See more keywords