Investigation of antioxidant and anti‐nociceptive potential of isoxazolone, pyrazolone derivatives, and their molecular docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21711
Abstract: A series of new isoxazolone (3a–d) and pyrazolone (4a–d) derivatives were synthesized and assessed for their antioxidant and analgesic activity. Among synthesized compounds, 3b and 4b having nitro (NO2) group show high analgesic activity at… read more here.
Keywords: pyrazolone derivatives; analgesic activity; potential isoxazolone; isoxazolone pyrazolone ... See more keywords
Mitigation of acid corrosion on carbon steel by novel pyrazolone derivatives
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DOI: 10.1039/c7ra08761f
Abstract: For the corrosion of carbon steel in 1.0 M HCl solution, the new pyrazolone derivatives (PY1 and PY2) have been identified as active corrosion inhibitors. Clear evidence of the inhibitory effect of pyrazolone derivatives is… read more here.
Keywords: pyrazolone derivatives; corrosion; carbon steel;
Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc01123e
Abstract: An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and… read more here.
Keywords: substituted pyrazolone; derivatives bearing; pyrazolone; construction alkenyl ... See more keywords
Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant Properties
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DOI: 10.3390/molecules28083491
Abstract: Orally-active anticancer small molecules targeting the PD-1/PD-L1 immune checkpoint are actively searched. Phenyl-pyrazolone derivatives with a high affinity for PD-L1 have been designed and characterized. In addition, the phenyl-pyrazolone unit acts as a scavenger of… read more here.
Keywords: targeted phenyl; novel targeted; antioxidant properties; pyrazolone ... See more keywords