Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00758
Abstract: The enterovirus genus of the picornavirus family contains many important human pathogens. EV-D68 primarily infects children, and the disease manifestations range from respiratory illnesses to neurological complications such as acute flaccid myelitis (AFM). EV-A71 is… read more here.
Keywords: d68 a71; potent broad; pyrazolopyridine containing; viral protein ... See more keywords
Recent Advances in the Development of Pyrazolopyridines as Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210901102832
Abstract: Cancer, especially malignant tumor, is a serious threat to people's life and health. It is recognized as an enormous challenge in the 21st century. Continuous efforts are needed to overcome this problem. Pyrazolopyridine nucleus, similar… read more here.
Keywords: anticancer agents; advances development; development pyrazolopyridines; pyrazolopyridines anticancer ... See more keywords