Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein.
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DOI: 10.1021/acs.jmedchem.1c00758
Abstract: The enterovirus genus of the picornavirus family contains many important human pathogens. EV-D68 primarily infects children, and the disease manifestations range from respiratory illnesses to neurological complications such as acute flaccid myelitis (AFM). EV-A71 is… read more here.
Keywords: d68 a71; potent broad; pyrazolopyridine containing; viral protein ... See more keywords