Design, Synthesis, Docking Studies, and Investigation of Dual EGFR/VEGFR‐2 Inhibitory Potentials of New Pyrazole and Pyrazolopyridine Derivatives
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DOI: 10.1002/ddr.70056
Abstract: The anticancer potential of certain newly synthesized pyrazole and pyrazolopyridine derivatives has been estimated. NCI 60 cancer cells cytotoxic screening pointed out compounds 3e and 3f as the highest cytotoxic agents with % mean growth… read more here.
Keywords: pyrazole pyrazolopyridine; vegfr; egfr vegfr; dual egfr ... See more keywords
Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00238
Abstract: In spite of the great success of immune checkpoint inhibitors in immune-oncology therapy, an urgent need still exists to identify alternative approaches to broaden the scope of therapeutic coverage. Hematopoietic progenitor kinase 1 (HPK1), also… read more here.
Keywords: derivatives hpk1; discovery pyrazolopyridine; chemistry; pyrazolopyridine derivatives ... See more keywords