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   Articles with "pyridazin one" as a keyword



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Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity

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recommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"

DOI: 10.1021/acsmedchemlett.1c00633

Abstract: Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at different… read more here.

Keywords: one based; guanidine; pyridazin one; minor groove ... See more keywords
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Structure and cytotoxic properties of 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one and its mono- and disubstituted ethyl acetates.

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recommendations! Published in 2022 at "Acta crystallographica. Section C, Structural chemistry"

DOI: 10.1107/s2053229622009202

Abstract: Derivatives of pyrido[3,4-d]pyridazine, namely, 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one dimethylformamide monosolvate, C14H11N3O2·C3H7NO (2), ethyl [1-(2-ethoxy-2-oxoethoxy)-5-methyl-4-oxo-7-phenyl-3,4-dihydropyrido[3,4-d]pyridazin-3-yl]acetate, C18H17N3O4 (3), and ethyl [(5-methyl-4-oxo-7-phenyl-3,4-dihydropyrido[3,4-d]pyridazin-1-yl)oxy]acetate, C22H23N3O6 (4), were synthesized with the aim of discovering new potential biologically active agents. The properties of all three… read more here.

Keywords: pyridazin one; hydroxy methyl; methyl phenylpyrido; phenylpyrido pyridazin ... See more keywords
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Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds.

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recommendations! Published in 2019 at "Future medicinal chemistry"

DOI: 10.4155/fmc-2019-0160

Abstract: Aim: Hypertension is a major health problem worldwide resulting in high death rates due to its consequences and complications. Therefore, searching for new vasorelaxants is a must to find new vasodilators efficient for the treatment… read more here.

Keywords: synthesis vasodilator; one based; vasodilator activity; activity ... See more keywords