Design, Synthesis, and Bioactivity Evaluation of Novel 3‐(Substituted Phenoxy)‐6‐Methyl‐4‐(3‐Trifluoromethylphenyl) Pyridazine Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2640
Abstract: Using 3-(4-cyano phenoxy)-6-methyl-4-(3-trifluoromethylphenyl) pyridazine (compound ) as a leading compound, a total of 24 novel 3-(substituted phenoxy)-6-methyl-4-(3-trifluoromethylphenyl) pyridazine derivatives containing two electron-withdrawing groups on the benzene ring (acylamine and oxime ether) were synthesized. Their herbicidal,… read more here.
Keywords: methyl trifluoromethylphenyl; trifluoromethylphenyl pyridazine; phenoxy methyl; pyridazine derivatives ... See more keywords
Synthesis, crystal structure characterization, DFT calculations, Hirshfeld surface analysis and 3D energy frameworks of triazole pyridazine derivatives: Theoretical and experimental studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131242
Abstract: Abstract Recently, pyridazine derivatives have shown considerable biological properties such as anti-tumor and anti-inflammatory activity. The studied compounds 6-chloro-3-[(4-methylphenoxy)methyl][1,2,4] triazolo[4,3-b]pyridazine (8a) and 6-chloro-3-[(4-fluorophenoxy)methyl][1,2,4] triazolo[4,3-b]pyridazine (8b) have been synthesized and characterized by NMR, IR and mass… read more here.
Keywords: theoretical experimental; pyridazine; hirshfeld surface; pyridazine derivatives ... See more keywords
Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone
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DOI: 10.1039/d0qo00955e
Abstract: A method for the synthesis of pertrifluoromethyl pyridazine derivatives by the condensation of arenediazonium salts with hexafluoroacetylacetone has been developed. read more here.
Keywords: salts hexafluoroacetylacetone; pyridazine derivatives; derivatives via; pertrifluoromethyl pyridazine ... See more keywords
Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents
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DOI: 10.2478/acph-2019-0015
Abstract: Abstract In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed through the reaction of cyanoacetic acid hydrazide with carbon disulfide in alcoholic… read more here.
Keywords: pyridazine derivatives; reaction; virus; compound ... See more keywords