Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.035
Abstract: Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here we describe the development of two… read more here.
Keywords: anti inflammatory; pyridazinone derivatives; derivatives potential; biological evaluation ... See more keywords
Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00631
Abstract: To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal… read more here.
Keywords: kinase; tyrosine kinase; activity; fer tyrosine ... See more keywords
3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra06892a
Abstract: Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. read more here.
Keywords: pyridazinone derivatives; novel plant; plant activators; new scaffold ... See more keywords
Synthesis, Spectroscopic Characterization, Antibacterial Activity, and Computational Studies of Novel Pyridazinone Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020678
Abstract: In this work, a novel series of pyridazinone derivatives (3–17) were synthesized and characterized by NMR (1H and 13C), FT-IR spectroscopies, and ESI-MS methods. All synthesized compounds were screened for their antibacterial activities against Staphylococcus… read more here.
Keywords: characterization antibacterial; antibacterial activity; pyridazinone; pyridazinone derivatives ... See more keywords