C5‐Iminosugar modification of casein kinase 1δ lead 3‐(4‐fluorophenyl)‐5‐isopropyl‐4‐(pyridin‐4‐yl)isoxazole promotes enhanced inhibitor affinity and selectivity
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DOI: 10.1002/ardp.202100497
Abstract: The quest for isoform‐selective and specific ATP‐competitive protein kinase inhibitors is of great interest, as inhibitors with these qualities will come with reduced toxicity and improved efficacy. However, creating such inhibitors is very challenging due… read more here.
Keywords: isopropyl pyridin; fluorophenyl isopropyl; casein kinase; pyridin isoxazole ... See more keywords