Synthesis and evaluation of anticonvulsant activities of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐b ]pyridine derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900106
Abstract: A series of 7‐phenyl‐4,5,6,7‐tetrahydrothieno[3,2‐b]pyridine derivatives containing triazole and other heterocycle substituents (methyltriazole, tetrazole, and triazolone) is described. Two experimental methods, maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ), were used to evaluate the anticonvulsant activity of… read more here.
Keywords: pyridine; tetrahydrothieno pyridine; evaluation anticonvulsant; synthesis evaluation ... See more keywords
Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100092
Abstract: This study describes the direct synthesis of 2‐amino‐4‐(phenylsubstituted)‐5H‐indeno[1,2‐b]pyridine‐3‐carbonitrile derivatives 5–21, through sequential multicomponent reaction of aromatic aldehydes, malononitrile, and 1‐indanone in the presence of ammonium acetate and acetic acid (catalytic). The biological study showed that… read more here.
Keywords: pyridine; antimetastatic activities; cell lines; indeno pyridine ... See more keywords
Synthesis and Characterization of Pyridine Compounds for Amperometric Measurements of Leukocyte Esterase
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DOI: 10.1002/cbic.201800164
Abstract: We introduce a new class of substrates (compounds I–III) for leukocyte esterase (LE) that react with LE yielding anodic current in direct proportion to LE activity. The kinetic constants Km and kcat for the enzymatic… read more here.
Keywords: pyridine; compounds amperometric; characterization pyridine; leukocyte esterase ... See more keywords
Chiral superstructures from homochiral Zn2+ , Co2+ , Fe2+ -2,6-bis (aryl ethylimine)pyridine complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23115
Abstract: We report the hierarchical supramolecular organization of metallosupramolecular homochiral complexes 1-Λ-(S,S,S,S)-M2+ /1-∆-(R,R,R,R)-M2+ and 2- Λ-(S,S,S,S)-M2+ /2-∆- (R,R,R,R)-M2+ of M2+ = Co2+ , Fe2+ , Zn2+ metal ions with chiral pseudo-terpyridine-type ligands: 1-(S,S) or 1-(R,R) =… read more here.
Keywords: co2 fe2; pyridine; chiral superstructures; bis ... See more keywords
A Modular Synthesis of Teraryl‐Based α‐Helix Mimetics, Part 5: A Complete Set of Pyridine Boronic Acid Pinacol Esters Featuring Side Chains of Proteinogenic Amino Acids
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202101280
Abstract: Abstract Teraryl‐based α‐helix mimetics have proven to be useful compounds for the inhibition of protein‐protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl‐based α‐helix mimetics using pyridine containing… read more here.
Keywords: based helix; pyridine; boronic acid; teraryl ... See more keywords
Preparation, DFT calculations, docking studies, antioxidant, and anticancer properties of new pyrazole and pyridine derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23135
Abstract: Seven novel pyrazole derivatives (4a–g) and four novel starting compounds incorporating substituted pyridine moieties were synthesized successfully. Cell viability assay for the tested compounds was performed, and the inhibitory concentrationlogarithmic 50 (LogIC50) values of the… read more here.
Keywords: preparation dft; pyridine; activity; docking studies ... See more keywords
New fluorinated copoly(pyridine ether imide)s derived from 4,4′-oxydianiline, pyromellitic dianhydride and 4-(4-trifluoromethylphenyl)-2,6-bis[4-(4-amino-2-trifluoromethylphenoxy)phenyl]pyridine
Sign Up to like & getrecommendations! Published in 2018 at "Polymer Bulletin"
DOI: 10.1007/s00289-018-2585-6
Abstract: Abstract A new aromatic diamine, 4-(4-trifluoromethylphenyl)-2,6-bis[4-(4-amino-2-trifluoromethylphenoxy)phenyl]pyridine (9FPBAPP), was prepared from 4-(4-trifluoromethylphenyl)-2,6-bis(4-hydroxyphenyl)pyridine with 2-chloro-5-nitrotrifluoromethylbenzene by substitution and reduction reactions successively. A series of fluorinated copoly(pyridine ether imide)s were prepared from 4,4′-oxydianiline (ODA), pyromellitic dianhydride and 9FPBAPP… read more here.
Keywords: amino trifluoromethylphenoxy; trifluoromethylphenyl bis; pyridine; bis amino ... See more keywords
A convenient synthesis method of 5-oxopyrazolo[4,3-b]pyridine-6-carboxylic acids and their nitriles
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02603-5
Abstract: N-Boc-protected 5-formyl-1H-pyrazol-4-amines react with malonic acid in pyridine in the presence of pyrrolidine at 45–50°С or with malonic acid monomethyl ether in the presence of pyrrolidine in AcOH under reflux with the formation of 5-oxo-4,5-dihydro-1Hpyrazolo[4,3-b]pyridine-6-carboxylic… read more here.
Keywords: presence pyrrolidine; carboxylic acids; pyridine; pyridine carboxylic ... See more keywords
Synthesis of pyrrolo[3,4-c]pyridine-1,3-diones (5-azaphthalimides) (microreview)
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02693-6
Abstract: The review summarizes the work devoted to the preparation of pyrrolo[3,4-c]pyridine-1,3-dione (5-azaphthalimide) derivatives over the last 10 years. Methods for the synthesis of pyrrolo[3,4-c]pyridine-1,3-dione derivatives are divided into three groups: annulation of the pyrrole moiety,… read more here.
Keywords: pyridine diones; pyrrolo pyridine; pyridine; synthesis pyrrolo ... See more keywords
The novel pyridine based symmetrical Schiff base ligand and its transition metal complexes: synthesis, spectral definitions and application in dye sensitized solar cells (DSSCs)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Materials Science: Materials in Electronics"
DOI: 10.1007/s10854-017-7986-z
Abstract: The pyridine based azo-linked symmetrical Schiff base ligand, (E)-2,2′-((1E,1′E)-(pyridine-2,6-diylbis(azanylylidene))bis(methanylylidene))bis(4-((E)-phenyldiazenyl)phenol) (H2L), and its Co(II), Ni(II) and Pd(II) transition metal complexes were prepared, and defined by using elemental analysis, Fourier transform infrared, UV–visible, mass, nuclear magnetic resonance… read more here.
Keywords: pyridine; transition metal; metal; metal complexes ... See more keywords
Pot, atom and step economic (PASE) assembly of salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones into medicinally relevant 5H-chromeno[2,3-b]pyridine scaffold
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-019-09968-x
Abstract: The new multicomponent reaction (MCR) has been found: one-pot selective and efficient formation of the new 5-(4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-substituted 5H-chromeno[2,3-b]pyridines in 61–97% yields directly from simple and easily available salicylaldehydes, malononitrile dimer and 4-hydroxypyridine-2(1H)-ones in small amount… read more here.
Keywords: hydroxypyridine ones; pyridine; dimer hydroxypyridine; chromeno pyridine ... See more keywords