Synthesis of Polysubstituted Cyclohexenes via Pyridine-Boryl Radical-Catalyzed Formal [4 + 2] Cycloadditions of Cyclobutanes with Alkynes.
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DOI: 10.1021/acs.orglett.5c02553
Abstract: Polysubstituted cyclohexene derivatives widely exist in pharmaceuticals and bioactive natural products. Herein, we report the first pyridine-boryl radical-catalyzed intermolecular formal [4 + 2] cycloadditions between cyclobutanes and alkynes, producing tri- and tetrasubstituted cyclohexene derivatives with… read more here.
Keywords: formal cycloadditions; cycloadditions cyclobutanes; cyclobutanes alkynes; pyridine boryl ... See more keywords
Metal-Free Synthesis of C-4 Substituted Pyridine Derivatives Using Pyridine-boryl Radicals via a Radical Addition/Coupling Mechanism: A Combined Computational and Experimental Study.
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DOI: 10.1021/jacs.7b00823
Abstract: Density functional theory investigations revealed that the pyridine-boryl radical generated in situ using 4-cyanopyridine and bis(pinacolato)diboron could be used as a bifunctional "reagent", which serves as not only a pyridine precursor but also a boryl… read more here.
Keywords: mechanism; addition; pyridine boryl; substituted pyridine ... See more keywords