Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents.
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DOI: 10.1021/acs.jmedchem.9b01275
Abstract: Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective agent. Uncapable of synthesizing purines de novo, this parasite depends on acquisition and… read more here.
Keywords: pyridine dideazapurine; pyrrolo pyridine; nucleoside analogues; trypanosoma cruzi ... See more keywords