One-pot synthesis of 3-hydroxy-2-oxindole-pyridine hybrids via Hantzsch ester formation, oxidative aromatization and sp3 CH functionalization using FeWO4 nanoparticles as recyclable heterogeneous catalyst
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DOI: 10.1016/j.catcom.2017.09.027
Abstract: Abstract Synthesis of poly-substituted 3-hydroxy-2-oxindole-pyridine hybrids is reported via sp 3 C H bond functionalization as key steps using FeWO 4 nanoparticles as reusable heterogeneous catalyst. Formation of Hantzsch ester (DHP) followed by aromatization, and… read more here.
Keywords: oxindole pyridine; pyridine; heterogeneous catalyst; hydroxy oxindole ... See more keywords
Synthesis and antibiofilm activity of 1,2,3-triazole-pyridine hybrids against methicillin-resistant Staphylococcus aureus (MRSA)
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DOI: 10.1039/d1nj00773d
Abstract: Antibiotic-resistant bacteria are emerging at an alarming rate, posing a potential threat to human health. A series of 1,2,3-triazole-pyridine hybrids were synthesised as promising antibiofilm agents against planktonic and sessile MRSA. read more here.
Keywords: activity triazole; antibiofilm activity; pyridine hybrids; synthesis antibiofilm ... See more keywords
New bis(thieno[2,3-b]pyridine) hybrids linked to arene units as potential bacterial biofilm and MRSA inhibitors
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DOI: 10.1139/cjc-2022-0236
Abstract: Using sonication and mediated by piperazine, new arene-linked bis(thieno[2,3-b]pyridine) hybrids were efficiently prepared in this study. The target hybrids were prepared by reacting bis(α-haloketone) with two equivalents of the appropriate pyridine-2(1H)-thiones in the presence of… read more here.
Keywords: bis thieno; pyridine hybrids; biofilm; thieno pyridine ... See more keywords
Challenging breast cancer through novel sulfonamide-pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.
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DOI: 10.4155/fmc-2022-0197
Abstract: Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide-pyridine hybrids (2-12) were designed, synthesized and biologically evaluated for their potential… read more here.
Keywords: sulfonamide pyridine; pyridine hybrids; breast; breast cancer ... See more keywords