Visible-Light-Promoted Photoaddition of N-Nitrosopiperidines to Alkynes: Continuous Flow Chemistry Approach to Tetrahydroimidazo[1,2-a]pyridine 1-Oxides.
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DOI: 10.1021/acs.orglett.2c02402
Abstract: The photoaddition of N-nitrosopiperidines to terminal alkynes was effected under visible-light irradiation, in which a novel synthetic access to tetrahydroimidazo[1,2-a]pyridine 1-oxides was achieved via the dehydrogenative cycloisomerization of β-nitroso enamine intermediates. The decomposition pathways of… read more here.
Keywords: tetrahydroimidazo pyridine; photoaddition nitrosopiperidines; chemistry; pyridine oxides ... See more keywords
Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.
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DOI: 10.1021/acs.orglett.7b01481
Abstract: A novel three-component reaction of pyridine N-oxides, acyl chlorides, and cyclic ethers is described. Treatment of an electron-deficient pyridine N-oxide with an acyl chloride in the presence of a cyclic ether at 25-50 °C leads… read more here.
Keywords: pyridine; reaction pyridine; pyridine oxides; three component ... See more keywords
Copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes.
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DOI: 10.1039/d2cc00851c
Abstract: A general and expedient method to construct the scaffolds of 2-alkenylpyridines, through copper-catalyzed C2 alkenylation of pyridine-N-oxides with alkynes, has been disclosed. This protocol shows operational simplicity, good functional group compatibility and broad substrate scope. read more here.
Keywords: alkenylation pyridine; catalyzed alkenylation; oxides alkynes; copper catalyzed ... See more keywords
Pyridine N-oxides as HAT reagents for photochemical C-H functionalization of electron-deficient heteroarenes.
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DOI: 10.1039/d2cc03772f
Abstract: Pyridine N-oxides have only recently marked their presence in the photocatalysis field, mainly serving as oxypyridinium salt precursors. Herein, their unique reactivity as a hydrogen atom transfer reagent in photochemical, Minisci-type alkylation of electron-deficient heteroarenes… read more here.
Keywords: electron deficient; hat reagents; deficient heteroarenes; pyridine oxides ... See more keywords