Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00394
Abstract: 2-Amino-9H-pyrido[2,3-b]indole (AαC) is the most abundant carcinogenic heterocyclic aromatic amine (HAA) formed in mainstream tobacco smoke. AαC is a liver carcinogen in rodents, but its carcinogenic potential in humans is not known. To obtain a… read more here.
Keywords: amino pyrido; pyrido indol; gluc; pyrido indole ... See more keywords
TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2-b][1,2,4]triazine and Pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c01980
Abstract: An efficient high-pressure-assisted trifluoroacetic acid-catalyzed protocol for synthesizing unreported novel pyrido[1,2-b][1,2,4]triazine and pyrido[1′,2′:2,3][1,2,4]triazino[5,6-b]indole derivatives has been established. This strategy includes the condensation reactions of various 1-amino-2-imino-4-arylpyridine-3-carbonitrile derivatives with indoline-2,3-dione (isatin) derivatives and α-keto acids such… read more here.
Keywords: strategy; tube reactor; pyrido triazine; pyrido ... See more keywords
Investigation of the radical scavenging potential of vanillin-based pyrido-dipyrimidines: experimental and in silico approach
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra02469e
Abstract: Antioxidants have a significant contribution in the cell protection against free radicals which may induce oxidative stress, and permanently damage the cells causing different disorders such as tumors, degenerative diseases, and accelerated aging. Nowadays, a… read more here.
Keywords: potential vanillin; vanillin based; vanillin; pyrido ... See more keywords
Synthesis and characterization of new pyrido-thieno-pyrimidine derivatives incorporating pyrazole moiety
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DOI: 10.1080/00397911.2017.1370113
Abstract: ABSTRACT 2-Hydrazinyl-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one was reacted with commercially available active methylene compounds (e.g., acetylacetone, ethyl acetoacetate, and diethyl malonate) and ethoxymethylenemalononitrile to afford the respective pyrazole derivatives. Moreover, the prepared pyrazolinone was utilized for synthesis of some… read more here.
Keywords: characterization new; pyrido thieno; synthesis characterization; pyrido ... See more keywords
Facile synthesis and characterization of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one and pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine incorporating 1,3-diarylpyrazole moiety
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1468911
Abstract: Abstract 4-(3-(4-Hydroxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-di hydro-pyridine-3-carbonitrile (1) reacted with ethyl chloroacetate (2) in ethanolic sodium acetate solution to yield the corresponding ethyl (3-cyanopyridin-2-ylsulphanyl)acetate derivative 3. Intramolecular cyclization of compound 3 was achieved by its heating in DMF containing… read more here.
Keywords: pyrido pyrazolo; pyrimidin one; pyrido thieno; pyrazolo ... See more keywords
Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
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DOI: 10.3390/molecules28052099
Abstract: Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold… read more here.
Keywords: exploration pyrido; pyrimidines antagonists; pyrido; cxcr2 ... See more keywords