QSAR studies of new pyrido[3,4-b]indole derivatives as inhibitors of colon and pancreatic cancer cell proliferation
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2250-5
Abstract: We have discovered a new class of pyrido[b]bindole derivatives that show potent and broad spectrum anticancer activity with IC50 values down to submicromolar levels. Structure–activity relationship data acquired with the compounds as antiproliferative agents against… read more here.
Keywords: pancreatic cancer; qsar; cancer cell; cell ... See more keywords
Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00394
Abstract: 2-Amino-9H-pyrido[2,3-b]indole (AαC) is the most abundant carcinogenic heterocyclic aromatic amine (HAA) formed in mainstream tobacco smoke. AαC is a liver carcinogen in rodents, but its carcinogenic potential in humans is not known. To obtain a… read more here.
Keywords: amino pyrido; pyrido indol; gluc; pyrido indole ... See more keywords
Design, synthesis and biological evaluation of 9-aryl-5H-pyrido[4,3-b]indole derivatives as potential tubulin polymerization inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.1004835
Abstract: A series of new 9-aryl-5H-pyrido[4,3-b]indole derivatives as tubulin polymerization inhibitors were designed, synthesized, and evaluated for antitumor activity. All newly prepared compounds were tested for their anti-proliferative activity in vitro against three different cancer cells… read more here.
Keywords: tubulin polymerization; polymerization inhibitors; indole derivatives; aryl pyrido ... See more keywords