An efficient synthesis of new polyfunctional hexahydro pyrido[1,2-a]pyrazin-1-ones
Sign Up to like & getrecommendations! Published in 2021 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2021.03.039
Abstract: New polyfunctional hydrogenated pyrido[1,2-a]pyrazin- 1-ones were obtained by regioselective recyclization of N-arylitaconimides with alkyl (3-oxopiperazin-2-ylidene)acetates. The supposed cascade reaction pathway involves the Michael addition of the nucleophile to an activated double bond and subsequent intramolecular… read more here.
Keywords: pyrido pyrazin; new polyfunctional; efficient synthesis; pyrazin ones ... See more keywords
Design, synthesis, anticancer evaluation and molecular docking studies of chalcone linked pyrido[4,3-b]pyrazin-5(6H)-one derivatives
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DOI: 10.1016/j.molstruc.2020.129851
Abstract: Abstract A series of novel chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) were designed, synthesized and their structures were confirmed by 1H NMR, 13C NMR and mass spectral data. Further, all derivatives were tested for their anticancer activities… read more here.
Keywords: pyrazin one; pyrido pyrazin; cancer; anticancer ... See more keywords