Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
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DOI: 10.1021/acsmedchemlett.8b00631
Abstract: To obtain a new anticancer drug, we focused on FER tyrosine kinase. Starting with high-throughput screening with our in-house chemical library, compound 1, which has a pyridine moiety, was found. Referring to their X-ray crystal… read more here.
Keywords: kinase; tyrosine kinase; activity; fer tyrosine ... See more keywords