β-Cyclodextrin as a Biomimetic Catalyst for the Efficient Synthesis of 4-Oxo-pyrido[1,2-a] Pyrimidine-3-Carbonitrile in Aqueous Medium
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Letters"
DOI: 10.1007/s10562-017-1983-y
Abstract: Supramolecular β-cyclodextrin as a highly efficient, biodegradable, and reusable catalyst for the synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives (4a–s) is investigated via a cascade reaction of aldehydes, malanonitrile and 2-aminopyridine in aqueous medium at 65 °C under ultrasonication.… read more here.
Keywords: oxo pyrido; pyrimidine carbonitrile; pyrido pyrimidine; catalyst ... See more keywords
An efficient one-pot synthesis of highly functionalized benzylpyrazolyl pyrido[1,2-a]pyrimidine derivatives using CuFe2O4 nanoparticles under solvent-free conditions
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3022-4
Abstract: An efficient and green protocol for the synthesis of novel benzylpyrazolyl pyrido[1,2-a]pyrimidine derivatives via three-component reaction of aryl aldehydes, 2-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-ones, and 3-methyl-1-phenyl-1H-pyrazol-5-one has been reported using a magnetically separable and reusable heterogeneous copper ferrite (CuFe2O4)… read more here.
Keywords: free conditions; benzylpyrazolyl pyrido; pyrimidine derivatives; pyrimidine ... See more keywords
Investigating structural aspects of Pyridopyrimidinone derivatives, an important precursor in medicinal chemistry
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129040
Abstract: Abstract Pyridopyrimidinones are class of heterocyclic compounds which serves as important precursors in organic transformation and medicinal chemistry. In the current work three derivatives of pyrido[1,2-a]pyrimidine-3-carboxylates (1, 2 and 3) has been synthesized and characterized… read more here.
Keywords: investigating structural; medicinal chemistry; chemistry; pyrimidine carboxylates ... See more keywords
Discovery of Pyrido[1,2-a]pyrimidine Mesoionic Compounds Containing Benzo[b]thiophene Moiety as Potential Pesticide Candidates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01899
Abstract: The increasing evolution of insect resistance has made it challenging for traditional insecticides to control the bean aphid (Aphis craccivora Koch). To address this pending issue, a range of pyrido[1,2-a]pyrimidine mesoionic compounds containing benzo[b]thiophene were… read more here.
Keywords: mesoionic compounds; containing benzo; pyrimidine mesoionic; compounds containing ... See more keywords
Synthesis and Herbicidal Activity of Pyrido[2,3-d]pyrimidine-2,4-dione-Benzoxazinone Hybrids as Protoporphyrinogen Oxidase Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01990
Abstract: To search for new protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors with improved bioactivity, a series of novel pyrido[2,3-d]pyrimidine-2,4-dione-benzoxazinone hybrids, 9-13, were designed and synthesized. Several compounds with improved tobacco PPO (mtPPO)-inhibiting and promising herbicidal activities… read more here.
Keywords: dione; protoporphyrinogen oxidase; dione benzoxazinone; pyrimidine dione ... See more keywords
18F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor.
Sign Up to like & getrecommendations! Published in 2017 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.6b00520
Abstract: In nonsmall-cell lung carcinoma patients, L858R mutation of epidermal growth factor receptor (EGFR) is often found, and molecular target therapy using EGFR tyrosine kinase inhibitors is effective for the patients. However, the treatment frequently develops… read more here.
Keywords: factor receptor; growth factor; pyrido pyrimidine; l858r mutant ... See more keywords
Synthesis of 2-Selenoxo-1,9a-Dihydro-2H-Pyrido [1,2-a]Pyrimidine Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2019.1656263
Abstract: Abstract A one-pot method for the synthesis of six novel 2-selenoxo-1,9a-dihydro-2H-pyrido[1,2-a]pyrimidine derivatives in good yields at room temperature has been achieved via reaction between isoselenocyanates, pyridines and acetylenic esters. read more here.
Keywords: pyrido pyrimidine; dihydro pyrido; selenoxo dihydro; pyrimidine derivatives ... See more keywords
Efficient Synthesis and Reactions of New Functionally Substituted Pyrido[2,3-d]pyrimidine Candidates
Sign Up to like & getrecommendations! Published in 2018 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363218060300
Abstract: Pyrido[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-hydrazinopyrido[2,3-d]-pyrimidin-4(3H)-one with different aryl aldehydes and active methylene compounds. Their structures were characterized by spectroscopic methods. read more here.
Keywords: synthesis reactions; efficient synthesis; reactions new; new functionally ... See more keywords
Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4- d]pyrimidines.
Sign Up to like & getrecommendations! Published in 2019 at "Current organic synthesis"
DOI: 10.2174/1570179416666190704113647
Abstract: The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds… read more here.
Keywords: pyrido pyrimidine; chemistry pyrido; pyrido pyrimidines; chemistry ... See more keywords
Graphene Oxide: A Carbocatalyst for the One-Pot Multicomponent Synthesis of 5-Aryl-1H-Indeno[2’,1’:5,6]Pyrido[2,3-d]Pyrimidine-2,4,6(3H)-Trione
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Research"
DOI: 10.3184/174751918x15161933697835
Abstract: A simple, straightforward and efficient method is described for the synthesis of 5-aryl-1H-indeno[2’,1’:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione via one-pot multicomponent reaction of indane-1,3-dione, arylaldehydes and 6-aminopyrimidin-2,4(1H,3H)-dione in presence of catalytic amount of graphene oxide in water. Graphene oxide is… read more here.
Keywords: pyrido pyrimidine; aryl indeno; graphene oxide; synthesis aryl ... See more keywords
Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052099
Abstract: Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold… read more here.
Keywords: exploration pyrido; pyrimidines antagonists; pyrido; cxcr2 ... See more keywords